{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282681376233344.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11405/nisshoshi1964.75.1768"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DyaE1M%2FptFynug%3D%3D"}},{"identifier":{"@type":"PMID","@value":"731984"}},{"identifier":{"@type":"NAID","@value":"130001062047"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1980009149"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"EFFECT OF URSODEOXYCHOLIC ACID ON CHOLESTEROL GALLSTONE DISSOLUTION"},{"@value":"ウルソデオキシコール酸によるコレステロール系胆石の溶解機序と血清胆汁酸の定量分析"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The dissolution of radiolucent gallstones was studied in 27 patients who were given 150mg, 300mg or 600mg of ursodeoxycholic acid (UDCA) per day during over 6 months. The gallstones completely disappeared in 6 cases (22.2%) and reduced in size and/or in number in 6 cases (22.2). In no-dissolved cases who were given UDCA over 12 months, gallstones did not reduce in size and/or in number by more long term treatment.<br>Total bile acid in serum increased to 3.8±5.24μg/ml (mean±SD, n=13) and UDCA occupied 54.2±15.9% after treatment, whereas it occupied 6.2±5.6% of total bile acid before treatment. Lithocholic acid (LCA) did not reveal in serum. An unknown compound was detected in serum of all cases after treatment by gas-liquid chromatography and the amount of this compound increased with increasing dose of UDCA. This compound was also detected in urine of treated patients and suspected as UDCA associated substance. In bile the ratio of UDCA to total bile acid increased significantly after treatment and the lithogenic index decreased. LCA in bile was slightly increased, but not significant. There was significant correlation between the lithogenic index and the UDCA ratio.<br>Serum cholesterol level increased in 7.1% and serum triglyceride level decreased in 7.7% after treatment, but not statistically significant.<br>Standard liver function tests remained normal during the treatment."},{"@value":"ursodeoxycholic acid (UDCA) を6カ月以上継続投与した radiolucent な胆石27例を対象とした. UDCA150mg/日投与群 (150mg 群) 4例, 300mg群10例, 600mg群13例で, 胆石溶解効果に対する有効率は44.4%であつた. 胆石消失群 (6例) では6カ月前後に縮小が認められ, 縮小•減少群 (6例) との間に, 効果発現までの期間 (縮小•減少群では9カ月前後) に有意差があつた. 1年を経過しても変化のないものは無効であつた. 大結石の溶解は, まず胆石表面が溶解し, それがある程度進むと胆石は崩壊して消失することが示唆された. 血清総胆汁酸値はUDCAの投与量に比例して増加し, 投与後に血清胆汁酸を分析しえた全例で, UDCAの服用と密接な関係にあると考えられる未知物質が検出された. 胆汁中胆汁酸組成比は, UDCAが投与量に伴つて増加し, それとともに lithogenic index は低下した. LCAの増加は有意ではなかつた. 血清脂質は投与前後で有意差がなかつた."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410572172180112771","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020469702"}],"foaf:name":[{"@language":"en","@value":"NAMBU Masaji"},{"@language":"ja","@value":"南部 勝司"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology, Internal Medicine, Juntendo University,"},{"@language":"ja","@value":"順天堂大学内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572172180112768","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020469709"}],"foaf:name":[{"@language":"en","@value":"KURODA Hiroyuki"},{"@language":"ja","@value":"黒田 博之"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology, Internal Medicine, Juntendo 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Minoru"},{"@language":"ja","@value":"前田 稔"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Section of Biochemistry, Tokyo Tanabe Research Laboratories"},{"@language":"ja","@value":"東京田辺製薬(株)"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"04466586"},{"@type":"EISSN","@value":"13497693"}],"prism:publicationName":[{"@language":"en","@value":"Nippon Shokakibyo Gakkai Zasshi"},{"@language":"ja","@value":"日本消化器病学会雑誌"},{"@language":"en","@value":"Nippon Shokakibyo Gakkai zasshi"},{"@language":"ja","@value":"日消誌"},{"@language":"en","@value":"Nippon Shokakibyo Gakkai Zasshi"},{"@language":"ja","@value":"日本消化器病学会雑誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Gastroenterology"},{"@language":"ja","@value":"一般財団法人 日本消化器病学会"}],"prism:publicationDate":"1978","prism:volume":"75","prism:number":"11","prism:startingPage":"1768","prism:endingPage":"1780"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/1980009149"}],"availableAt":"1978","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=ursodeoxycholic%20acid%20(UDCA)","dc:title":"ursodeoxycholic acid (UDCA)"},{"@id":"https://cir.nii.ac.jp/all?q=lithogenic%20index","dc:title":"lithogenic index"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%83%86%E7%9F%B3","dc:title":"胆石"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%83%86%E7%9F%B3%E6%BA%B6%E8%A7%A3","dc:title":"胆石溶解"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A1%80%E6%B8%85%E8%83%86%E6%B1%81%E9%85%B8","dc:title":"血清胆汁酸"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0030527561"},{"@type":"PUBMED","@value":"731984"},{"@type":"CIA","@value":"130001062047"}]}