ウイルス表面抗原タンパク質提示によるリポソームへの標的化能，細胞内侵入能，およびステルス能の付与

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タイトル別名
  • The Bio–nanocapsule: Versatile Liposome Armed with Virus–derived Functional Domain
  • ウイルス ヒョウメン コウゲン タンパクシツ テイジ ニ ヨル リポソーム エ ノ ヒョウテキカノウ,サイボウ ナイ シンニュウノウ,オヨビ ステルスノウ ノ フヨ

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説明

Some viruses that have nanoscale particle structures and infect humans can evade the recognition by the reticu-loendothelial system, circulate in blood stream, adsorb onto specific target cells, and finally enter into the cells. Theconsecutive actions strongly suggested that these viruses are naturally occurring nanomachines possessing the fol-lowing properties concurrently, stealth activity, targeting activity, and cell–penetrating activity. Since these proper-ties are caused by their envelope proteins, they can be applied for the design of efficient nanocarriers by incorporat-ing functional domains of their envelope proteins. In this review, we describe the development and utility of bio-nanocapsules, hybrids of human liver–specific hepatitis B virus envelope proteins and liposomes, as a drug deliverysystem. By modifying the surface of bio–nanocapsules with a variety of recognition molecules (e.g., antibodies,sugar chains, homing peptides), the technology can be used for targeting other organs.

収録刊行物

  • 膜

    膜 39 (5), 283-289, 2014

    日本膜学会

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