トキソプラズマ感染マウスにおけるガンマ・インターフェロンの産生増大
書誌事項
- タイトル別名
-
- Augmented production of gamma interferon in mice experimentally infected with Toxoplasma gondii.
- トキソプラズマ感染マウスにおけるガンマ・インターフェロンの産生増大〔英文〕
- トキソプラズマ カンセン マウス ニ オケル ガンマ インターフェロン ノ サ
この論文をさがす
説明
The gamma interferon (IFN-γ) production and the cell populations participating to this production were examined in Toxoplasma-infected mice. When spleen cells from Toxoplasma-infected mice were cultured with Concanavalin A (Con A) or OK-432, a Streptococcal preparation, they produced significantly high levels of IFN-γ as compared with that of noninfected mice. Such enhanced IFN titers were observed as early as at 5 days postinfection, reached at the maximum levels on 20 days around and declined gradually thereafter. Treatment of spleen cells from the infected mice with either monoclonal anti-Thy-1.2 antibody plus complement or macrophage-blocking agents virtually abolished the IFN production. The spleen cells producing IFN-γ were more susceptible to the treatment with monoclonal anti-Lyt-1.2 than anti-Lyt-2.2 antibodies, suggesting that CD4+ T cells are main producers of this lymphokine. When mice infected with Toxoplasma 10 days previously were injected with lipopolysaccharide (LPS), a well-known inducer of IFN-α/β, the sequential production of IFN-α/β and IFN-γ was induced in their circulation.
収録刊行物
-
- 日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
-
日本獸醫學雜誌(The Japanese Journal of Veterinary Science) 51 (2), 380-388, 1989
公益社団法人 日本獣医学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282681400403328
-
- NII論文ID
- 110003917978
-
- NII書誌ID
- AN00191788
-
- COI
- 1:CAS:528:DyaL1MXksFGnu7Y%3D
-
- ISSN
- 18811442
- 00215295
-
- NDL書誌ID
- 3237868
-
- PubMed
- 2500552
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可