Effects of Salivary Gland Extract from Rhipicephalus sanguineus on IgG Subclass Production and Cytokine mRNA Expression in Mononuclear Cells of Canine Peripheral Blood.

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  • MATSUMOTO Koutaro
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
  • INOKUMA Hisashi
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
  • OKUDA Masaru
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
  • ONISHI Takafumi
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

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  • Efffects of salivary gland extract from Rhipicephalus sanguineus on IgG subclass production and cytokine mRNA expression in mononuclear cells of canine peripheral blood

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The effects of salivary gland extract (SGE) from R. sanguineus were examined on the production of IgG1 and IgG2 and the mRNA expression of IFN-γ, IL-2, IL-4, IL-5 and IL-10 in the mononuclear cells from canine peripheral blood, treated with concanavalin A (ConA) in vitro. SGE suppressed the ConA-induced production of IgG2. It also inhibited the expression of IFN-γ, IL-2 and IL-5 mRNA in a dose-dependent manner. No dose-dependent suppression was observed of IL-10 mRNA expression although a significant effect was observed at a SGE protein concentration of 25 μg/ml. SGE had no effect on the mRNA expression of IL-4. These results suggest that the suppression of IgG2 production by SGE from R. sanguineus was caused by the suppression of IFN-γ production.<br>

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