Internal Medicine : Molecular cloning of feline resistin and the expression of resistin, leptin and adiponectin in the adipose tissue of normal and obese cats
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- TAKASHIMA Satoshi
- Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
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- NISHII Naohito
- Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
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- KATO Akiko
- Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
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- MATSUBARA Tatsuya
- Department of Veterinary Medicine, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
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- SHIBATA Sanae
- Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
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- KITAGAWA Hitoshi
- Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
書誌事項
- タイトル別名
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- Molecular cloning of feline resistin and the expression of resistin, leptin and adiponectin in the adipose tissue of normal and obese cats
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説明
Resistin, one of the adipokines that has a cycteine-rich C-terminus, is considered to relate to the development of insulin resistance in rats. However, in cats, there is little knowledge regarding resistin. In this study, we cloned the feline resistin cDNA from adipose tissue by RT-PCR. The feline resistin clone contained an entire open reading frame encoding 107 amino acids that had 72.8%, 75.4%, 50.9% and 51.8% homology with bovine, human, mouse and rat homologues, respectively. In both subcutaneous and visceral adipose tissues, the transcription levels of feline resistin mRNA were significantly higher in obese cats than normal cats, and those of feline adiponectin mRNA were significantly lower in obese cats than normal cats. However, there was no difference in the expression of feline leptin between normal and obese cats. On the other hand, in both normal and obese cats, there were no significant differences in resistin, leptin and adiponectin mRNA levels between subcutaneous and visceral adipose tissues. In cats, the altered expression of resistin and adiponectin mRNA with obesity may contribute to the pathogenesis of insulin resistance and subsequent diabetes mellitus. In addition to feline adiponectin, the feline resistin cDNA clone obtained in this study will be useful for further investigation of the pathogenesis of obesity in cats.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 78 (1), 23-28, 2016
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681406067200
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- NII論文ID
- 130005121591
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 027077333
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- PubMed
- 26256230
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可