マウス脳内法による百日咳ワクチン力価試験における免疫条件の研究

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タイトル別名
  • Studies on the Potency Test of Pertussis Vaccine by Intracerebral Method with special reference to the Host Factor
  • マウス ノウナイホウ ニ ヨル ヒャクニチゼキ ワクチン リキカ シケン ニ オケル メンエキ ジョウケン ノ ケンキュウ

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説明

The effects of pertussis vaccine on the host factor of the immunized mice were examined in respect to the route and period of immunization.<br>The mice immunized intraperitoneally with the doses of the protection test showed an increased sensi-tivity to histamine, intracerebral inoculation of sonic extract of Bordetella pertussis, and the intracerebral inoculation of living typhoid bacilli. And these effects were more remarkable at the 10th day after the im-munization than the later. However, the mice immunized subcutaneously did not show any increase of these sensitivity and protection.<br>On the other hand, the mice immunized intraperitoneally and boostered with 17 days interval showed better protection than 10 days interval, meaning the better establishment of the protection at the time of 17 days after the immunization.<br>From these results, including the reactivity to heterologous stresses and better response to the booster, . immunization period of 17 day is preferable to 10 day.

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