Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells
-
- MATSUURA Nobuyasu
- Department of Life Science, Faculty of Science, Okayama University of Science
-
- YAMADA Masashi
- Meiji Dairies Corporation
-
- SUZUKI Hiroto
- Meiji Dairies Corporation
-
- HASEGAWA Naoko
- Biotechnology Research Center, Toyama Prefectural University
-
- KUROSAKA Chihiro
- Biotechnology Research Center, Toyama Prefectural University
-
- UBUKATA Makoto
- Graduate School of Agriculture, Hokkaido University
-
- TANAKA Toshiyuki
- Gifu Prefectural Institute of Health and Environmental Sciences
-
- IINUMA Munekazu
- Gifu Pharmaceutical University
Search this article
Abstract
The effects of germacranolides isolated from Calea urticifolia on adipocytic differentiation of 3T3-L1 cells were examined. These germacranolides inhibited adipogenesis at a concentration of 1.25–5 μM. But no inhibitory activity against cell proliferation and no nonspecific binding activity to protein were observed. These results indicate that these germacranolides are the specific inhibitors of preadipocyte differentiation.
Journal
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 69 (12), 2470-2474, 2005
Japan Society for Bioscience, Biotechnology, and Agrochemistry
