{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282681456934656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1271/bbb.80323"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"9696830"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/9696830"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I9696830"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.1271/bbb.80323"}},{"identifier":{"@type":"NAID","@value":"10027532465"}}],"dc:title":[{"@language":"en","@value":"Exploring the Biosynthesis of Natural Products and Their Inherent Suitability for the Rational Design of Desirable Compounds through Genetic Engineering"},{"@value":"Award review: Exploring the biosynthesis of natural products and their inherent suitability for the rational design of desirable compounds through genetic engineering"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Much effort has been invested in studying how natural products are biosynthesized, and great advances have been made in understanding how these compounds acquire their structural complexity and biological activities. In recent years, significant progress has been made due to the devoted efforts of scientists in this field and to technological advancements. Numerous details, applications, and innovative findings have been elucidated by scientists using biochemical, genetic, and molecular biological approaches. Here I present a comprehensive overview of highly valued biosynthetic proteins, polyketide synthase and nonribosomal peptide synthetase. I begin with “Diels-Alderase” a captivating enzyme that has the ability to catalyze a Diels-Alder reaction valued by chemists for its usefulness in chemical synthesis. A handful of these enzymes have been characterized and chemically authenticated. The most well understood enzyme of this category is macrophomate synthase. Secondly, I focus on the polyketide and nonribosomal peptide biosynthetic pathways and the enzyme assembly for producing its metabolite. Many important natural products are produced by this biosynthetic pathway as secondary metabolites, such as erythromycin, rifamycin, and FK520, as antibiotics and an immunosuppressive, respectively. I conclude with a discussion of nonribosomal peptides and their mechanistic pathways. Special attention will be devoted to <I>de novo</I> production of echinomycin in a heterologous manner, the earliest example of totally engineered biosynthesis of the biologically active form of a nonribosomal peptide host in <I>Escherichia coli</I>."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326221550208","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50360938"},{"@type":"NRID","@value":"1000050360938"},{"@type":"NRID","@value":"9000006766176"},{"@type":"NRID","@value":"9000401962405"},{"@type":"NRID","@value":"9000257965586"},{"@type":"NRID","@value":"9000406289041"},{"@type":"NRID","@value":"9000410874499"},{"@type":"NRID","@value":"9000257965490"},{"@type":"NRID","@value":"9000382231161"},{"@type":"NRID","@value":"9000401545679"},{"@type":"NRID","@value":"9000412382349"},{"@type":"NRID","@value":"9000291273678"},{"@type":"NRID","@value":"9000273020065"},{"@type":"NRID","@value":"9000414102144"},{"@type":"NRID","@value":"9000311788766"},{"@type":"NRID","@value":"9000281375328"},{"@type":"NRID","@value":"9000253179401"},{"@type":"NRID","@value":"9000363283571"},{"@type":"NRID","@value":"9000019195547"},{"@type":"NRID","@value":"9000409026226"},{"@type":"NRID","@value":"9000018471704"},{"@type":"NRID","@value":"9000257965482"},{"@type":"NRID","@value":"9000019145232"},{"@type":"NRID","@value":"9000410922769"},{"@type":"NRID","@value":"9000019239598"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kenjiw"}],"foaf:name":[{"@language":"en","@value":"WATANABE Kenji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pharmacology and Pharmaceutical Sciences, University of Southern California"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09168451"},{"@type":"EISSN","@value":"13476947"},{"@type":"NDL_BIB_ID","@value":"000000151899"},{"@type":"ISSN","@value":"09168451"},{"@type":"LISSN","@value":"09168451"},{"@type":"NCID","@value":"AA10824164"}],"prism:publicationName":[{"@language":"en","@value":"Bioscience, Biotechnology, and Biochemistry"},{"@language":"ja","@value":"Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ"},{"@language":"en","@value":"Biosci. Biotechnol. Biochem."},{"@language":"en","@value":"Bioscience, Biotechnology, and Biochemistry"},{"@language":"ja","@value":"Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Bioscience, Biotechnology, and Agrochemistry"},{"@language":"ja","@value":"公益社団法人 日本農芸化学会"}],"prism:publicationDate":"2008","prism:volume":"72","prism:number":"10","prism:startingPage":"2491","prism:endingPage":"2506"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/9696830"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I9696830"},{"@id":"http://www.tandfonline.com/doi/pdf/10.1271/bbb.80323"}],"availableAt":"2008","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Diels-Alder%20reaction","dc:title":"Diels-Alder reaction"},{"@id":"https://cir.nii.ac.jp/all?q=biosynthesis","dc:title":"biosynthesis"},{"@id":"https://cir.nii.ac.jp/all?q=polyketide%20synthase","dc:title":"polyketide synthase"},{"@id":"https://cir.nii.ac.jp/all?q=nonribosomal%20peptide%20synthetase","dc:title":"nonribosomal peptide synthetase"},{"@id":"https://cir.nii.ac.jp/all?q=%3CI%3Ede%20novo%3C/I%3E%20production","dc:title":"<I>de novo</I> production"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292620679038208","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Reaction mechanism of the macrophomate synthase: experimental evidence on intermediacy of a bicyclic compound"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095524236032","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Modular Organization of Genes Required for Complex Polyketide Biosynthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044489354496","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519901295104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468845650560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Selective Protein−Protein Interactions Direct Channeling of Intermediates between Polyketide Synthase Modules"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894778490752","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795936094464","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Cloning and Heterologous Expression of the Epothilone Gene Cluster"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270009894784","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Production of the antimalarial drug precursor artemisinic acid in engineered yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270103575040","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Functional Cross-talk between Fatty Acid Synthesis and Nonribosomal Peptide Synthesis in Quinoxaline Antibiotic-producing Streptomycetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204149781376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp. II. Structure Elucidation."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206473587840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Potent Inhibition of Macrophomate Synthase by Reaction Intermediate Analogs."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679126480768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp. I. Taxonomy, Fermentation, Isolation and Biological Activities."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681450164992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Significance of the 20-kDa Subunit of Heterodimeric 2-Deoxy-scyllo-inosose Synthase for the Biosynthesis of Butirosin Antibiotics in Bacillus circulans."},{"@value":"Significance of the 20-kDa Subunit of Heterodimeric 2-Deoxy-<i>scyllo</i>-inosose Synthase for the Biosynthesis of Butirosin Antibiotics in<i>Bacillus circulans</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681451419648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Substrate Diversity of Macrophomate Synthase Catalyzing an Unusual Multistep Transformation from 2-Pyrones to Benzoates."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681454754560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Relative and Absolute Configuration of Antitumor Agent SW-163D"}]},{"@id":"https://cir.nii.ac.jp/crid/1523106604641971968","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Macrophomate Synthase:Characterization,Sequence,and Expression in Escherichia coli of the Novel Enzyme Catalyzing Unusual Multistep Transformation of 2-Pyrones to Benzoates"},{"@language":"ja-Kana","@value":"Macrophomate Synthase Characterization Sequence and Expression in Escherichia coli of the Novel Enzyme Catalyzing Unusual Multistep Transformation of 2 Pyrones to Benzoates"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750901160320","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biosynthesis of macrophomic acid: Plausible involvement of intermolecular diels-Alder reaction."}]},{"@id":"https://cir.nii.ac.jp/crid/1570009751817955456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhanced production of heterologous macrolide aglycones by fed-batch cultivation of Streptomyces coelicolor"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009752554903552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Novel biotransformation of a 2-pyrone to a substituted benzoic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224720337024","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Butirosin-biosynthetic Gene Cluster from Bacillus circulans"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226524541824","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Deconstruction of iterative multidomain polyketide synthase function"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226717423104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus."}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226723400576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A comparison of the structure of echinomycin and triostin A complexed to a DNA fragment"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699096621056","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Conversion of triostins to quinomycins by protoplasts of Streptomyces echinatus"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572701243843328","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572701515416960","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572701695237504","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"UK-63,052 complex, new quinomycin antibiotics from Streptomyces braegensis subsp. japonicus ; taxonomy, fermentation, isolation, characterisation and antimicrobial activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572701764238976","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The reaction cycle of isopenicillin N synthase observed by X-ray diffraction"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572702508977280","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group"},{"@language":"en","@value":"Studies on metabolities of Macrophoma commeliae. III."}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176493488128","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of the putative bryostatin polyketide synthase gene cluster from \"Candidatus Endobugula sertula,\" the uncultivated microbial symbiont of the marine bryozoan Bugula neritina"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176666072960","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Organization of the biosynthesis genes for the peptide antibiotic gramicidin S"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176765513216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176766591232","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651197190144","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification and stereochemical assignment of the β-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651197191424","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Polyketide and non-ribosomal peptide synthases : falling together by coming apart"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651736769280","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia toll as a heterologous host"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126173899776","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Breakdown of pulselabeled ribonucleic acid and polysomes in Bacillus megaterium : actions of streptolydigin, echinomycin, and triostin"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126173973888","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comprehensive natural products chemistry"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126622511744","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interaction of the antitumour antibiotic luzopeptin with the hexanucleotide duplex d(5'-GCATGC)2 : one-dimensional and two-dimensional n.m.r. studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126680148992","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Structure of a cephalosporin synthase"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126699884928","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599290572928","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Thiocoraline, a New Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora I. Taxonomy, Fermentation, Isolation, and Biological Activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601150610688","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601150687360","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Diels-Alder type natural products : structures and biosynthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601654293376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The DrrC protein of Streptomyces peucetius, a UvrA-like protein, is a DNA-binding protein whose gene is induced by daunorubicin"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601658982528","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Harnessing the biosynthetic code : combinations, permutations, and mutations"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074973573632","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076127321984","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"bryA : an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076657782272","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980077363785344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Isolation and structure of macommelins, novel metabolites of Macrophoma commelinae"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551560514816","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of the cyclic depsipeptide rings in antibiotics"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551626224256","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543023932611968","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A ^<15>N nuclear magnetic resonance study of the biosynthesis of quinoxaline antibiotics"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024928054016","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543026080742272","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Trapping and structure elucidation of an intermediate in the macrophomate synthase reaction pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026080745472","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bifunctional intercalation and sequence specificity in the binding of quinomycin and triostin antibiotics to deoxyribonucleic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026080818688","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Descriptive catalogue of IFO fungus collection V"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026544435328","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Footprinting studies of the interaction of quinomycin antibiotic UK63052 with DNA : comparison with echinomycin"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026579558272","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Solution structure of a quinomycin bisintercalator-DNA complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026626908800","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501057452800","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Production of quinomycin A in Streptomyces lasaliensis"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975648440960","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573105976034237184","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enzymatic catalysis of the Diels-Alder reaction in the biosynthesis of natural products"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976309452672","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular characterization of the safracin biosynthetic pathway from Pseudomonas fluorescens A2-2 : designing new cytotoxic compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976511189632","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573387451010875264","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A comprehensive and engaging overview of the type III family of polyketide 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