[Background]
Atopic dermatitis is a chronic, relapsing, intensely pruritic inflammatory skin disorder and it is difficult to completely cure. Recently, the therapeutic effect on atopic dermatitis by Toyotomi hot spring bathing has been reported. Therefore, the current study aimed to elucidate a mechanism of the effect.
[Methods]
In this study, a mouse model of atopic dermatitis was used. The therapeutic effect on atopic dermatitis of Toyotomi hot spring bathing and/or applying the oil that derived from Toyotomi hot spring was evaluated by comparing of severity scoring of atopic dermatitis (SCORAD).
[Results]
The value of SCORAD was tended to decrease in oil applying group as compared with the control group.
[Consideration]
The results in this study suggested some compound that has the therapeutic effect on atopic dermatitis is included in the oil derived from Toyotomi hot spring.
"},{"@language":"ja","@value":"背景・目的 アトピー性皮膚炎（Atopic Dermatitis, 以下AD）は、湿疹および慢性的なかゆみを伴い、増悪・寛解を繰り返す疾患で、根本的な治癒に至らない場合もある。本研究では近年AD寛解の症例が多数報告されている北海道豊富町の豊富温泉に注目し、そのAD抑制メカニズムの解明を目指した研究を実施した。
方法 本研究ではADモデルマウスを用いて、豊富温泉由来の温泉水および油分によるAD抑制効果を評価した。AD発症後に温泉水の水浴や油分の塗布を行い、重症度スコア（SCORAD）などでAD様症状を比較した。
結果 豊富温泉由来の油分を塗布した群では、コントロール群と比較してSCORADの値が減少傾向であった。
考察 豊富温泉由来の油分には、AD様症状を緩和する何らかの成分が含まれている可能性が示唆された。
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