{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282763130198144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3805/jjes.37.60"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jjes/37/1/37_60/_pdf"}},{"identifier":{"@type":"NAID","@value":"130007680200"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2019350330"}}],"dc:title":[{"@language":"en","@value":"A Case of Early Discontinuation of Antiepileptic Drugs for Psychiatric Comorbidity after Epilepsy Surgery"},{"@language":"ja","@value":"てんかん外科治療後に精神症状を顕在化したために術後早期に抗てんかん薬を減量した一例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>The safety and efficacy of epilepsy surgery for mesial temporal lobe epilepsy have been established. However, some patients show psychiatric comorbidity after epilepsy surgery. It is possible that psychiatric symptoms are induced by antiepileptic drugs (AED). An early withdrawal of AED after epilepsy surgery may be a risk factor for seizure recurrence.</p><p>Here we describe a case of a 19-year-old female who had intractable epilepsy. She also had focal impaired awareness seizures with epigastric rising sensation. She was diagnosed with right mesial temporal lobe epilepsy, and focus resection was thus performed. After epilepsy surgery she started having depression and aggression episodes. Therefore, the dosage of AED was reduced, and she started taking selective serotonin reuptake inhibitors at two months after surgery. Subsequently, psychiatric symptoms improved, and she remained seizure freedom.</p><p>Normal postoperative electroencephalogram findings, seizure freedom after epilepsy surgery, and complete resection may be the indications for the early withdrawal of AED.</p>"},{"@language":"ja","@value":"<p>内側側頭葉てんかんに対する外科手術は有効性が確立した治療法であり、発作消失のみならず精神症状の改善も認める。一方で、術後に精神症状を生じてしまうこともある。また抗てんかん薬による副作用でも精神症状をきたすことがあるが、術後早期の抗てんかん薬の内服の減量や中止はてんかん発作再発のリスクがあると報告されており、抗てんかん薬の減量は慎重に検討することが望ましいとされる。本症例は、右内側側頭葉てんかんに対し焦点切除術後よりうつ、易怒性を認めた。術後脳波所見が正常であり、発作も認めなかったため術後2カ月で抗てんかん薬の減量を行い、選択的セロトニン再取り込み阻害薬を開始したところ精神症状が改善した一症例を経験した。本症例より術後精神症状に対する治療について文献的考察を踏まえて報告する。</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751150061440","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30819222"},{"@type":"NRID","@value":"1000030819222"},{"@type":"NRID","@value":"9000019184006"},{"@type":"NRID","@value":"9000403298948"},{"@type":"NRID","@value":"9000409186796"},{"@type":"NRID","@value":"9000412343488"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/0104"}],"foaf:name":[{"@language":"en","@value":"Iimura Yasushi"},{"@language":"ja","@value":"飯村 康司"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"順天堂大学医学部付属順天堂医院脳神経外科"},{"@language":"en","@value":"Department of Neurosurgery, Juntendo University Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801191466112","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90265992"},{"@type":"NRID","@value":"1000090265992"},{"@type":"ORCID","@value":"0000-0002-7836-6585"},{"@type":"NRID","@value":"9000290820763"},{"@type":"NRID","@value":"9000406201428"},{"@type":"NRID","@value":"9000006262791"},{"@type":"NRID","@value":"9000253467029"},{"@type":"NRID","@value":"9000388994313"},{"@type":"NRID","@value":"9000319051277"},{"@type":"NRID","@value":"9000396114700"},{"@type":"NRID","@value":"9000402438650"},{"@type":"NRID","@value":"9000324996594"},{"@type":"NRID","@value":"9000402439894"},{"@type":"NRID","@value":"9000391520660"},{"@type":"NRID","@value":"9000006091852"},{"@type":"NRID","@value":"9000388997914"},{"@type":"NRID","@value":"9000388996587"},{"@type":"NRID","@value":"9000398778051"},{"@type":"NRID","@value":"9000410315167"},{"@type":"NRID","@value":"9000403298951"},{"@type":"NRID","@value":"9000409186795"},{"@type":"NRID","@value":"9000005452098"},{"@type":"NRID","@value":"9000412343490"},{"@type":"NRID","@value":"9000275829385"},{"@type":"NRID","@value":"9000345423174"},{"@type":"NRID","@value":"9000006352182"},{"@type":"NRID","@value":"9000391520669"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/juntendo"}],"foaf:name":[{"@language":"en","@value":"Sugano Hidenori"},{"@language":"ja","@value":"菅野 秀宣"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Neurosurgery, Juntendo University Hospital"},{"@language":"ja","@value":"順天堂大学医学部付属順天堂医院脳神経外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282763130198149","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000403298952"}],"foaf:name":[{"@language":"en","@value":"Arai Hajime"},{"@language":"ja","@value":"新井 一"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"順天堂大学医学部付属順天堂医院脳神経外科"},{"@language":"en","@value":"Department of Neurosurgery, Juntendo University Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282763130198147","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000403298947"}],"foaf:name":[{"@language":"en","@value":"Ueda Tetsuya"},{"@language":"ja","@value":"上田 哲也"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Neurosurgery, Juntendo University Hospital"},{"@language":"ja","@value":"順天堂大学医学部付属順天堂医院脳神経外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680032462469","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000345425445"},{"@type":"NRID","@value":"9000402438649"},{"@type":"NRID","@value":"9000410315161"},{"@type":"NRID","@value":"9000403298949"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tmituha"}],"foaf:name":[{"@language":"en","@value":"Mitsuhashi Takumi"},{"@language":"ja","@value":"三橋 匠"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"順天堂大学医学部付属順天堂医院脳神経外科"},{"@language":"en","@value":"Department of Neurosurgery, Juntendo University Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1420285329318419584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90884065"},{"@type":"NRID","@value":"1000090884065"},{"@type":"NRID","@value":"9000408895231"},{"@type":"NRID","@value":"9000399341277"},{"@type":"NRID","@value":"9000319051276"},{"@type":"NRID","@value":"9000403298950"},{"@type":"NRID","@value":"9000241559056"},{"@type":"NRID","@value":"9000345423173"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hiroharus"}],"foaf:name":[{"@language":"en","@value":"Suzuki Hiroharu"},{"@language":"ja","@value":"鈴木 皓晴"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"順天堂大学医学部付属順天堂医院脳神経外科"},{"@language":"en","@value":"Department of Neurosurgery, Juntendo University Hospital"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09120890"},{"@type":"LISSN","@value":"09120890"},{"@type":"EISSN","@value":"13475509"}],"prism:publicationName":[{"@language":"en","@value":"Journal of the Japan Epilepsy Society"},{"@language":"ja","@value":"てんかん研究"},{"@language":"en","@value":"JJES"},{"@language":"en","@value":"J.Jpn.Epil.Soc."},{"@language":"ja","@value":"てんかん研究"}],"dc:publisher":[{"@language":"en","@value":"JAPAN EPILEPSY SOCIETY"},{"@language":"ja","@value":"一般社団法人 日本てんかん学会"}],"prism:publicationDate":"2019-06-30","prism:volume":"37","prism:number":"1","prism:startingPage":"60","prism:endingPage":"66"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/jjes/37/1/37_60/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2019350330"}],"availableAt":"2019-06-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=mesial%20temporal%20lobe%20epilepsy","dc:title":"mesial temporal lobe epilepsy"},{"@id":"https://cir.nii.ac.jp/all?q=seizure%20recurrence","dc:title":"seizure recurrence"},{"@id":"https://cir.nii.ac.jp/all?q=antiepileptic%20drugs","dc:title":"antiepileptic drugs"},{"@id":"https://cir.nii.ac.jp/all?q=psychiatric%20comorbidity","dc:title":"psychiatric comorbidity"},{"@id":"https://cir.nii.ac.jp/all?q=early%20withdrawal","dc:title":"early withdrawal"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144992138624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Feasibility of antiepileptic drug withdrawal following extratemporal resective epilepsy surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621176087680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Don’t be afraid to treat depression in patients with epilepsy!"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093620877696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Psychiatric aspects of temporal lobe epilepsy before and after anterior temporal lobectomy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094959516288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Management of antiepileptic drugs following epilepsy surgery: A meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569441705344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Withdrawal of antiepileptic drugs after neocortical epilepsy surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045600208000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Peer support groups as an intervention to decrease epilepsy-associated stigma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518901189120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469741498624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impact of epilepsy surgery on seizure control and quality of life: A 26‐year follow‐up study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945431797120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discontinuation of Antiepileptic Drugs after Pediatric Epilepsy Surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418659667200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Psicosis epiléptica periictal, una causa de psicosis reversible"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368393628928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discontinuation of levetiracetam because of behavioral side 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