Secretory carcinoma (SC) is a low-grade salivary gland carcinoma similar to secretory breast carcinoma harboring the ETV6-NTRK3 fusion gene, that was first proposed as a distinct disease entity in 2010 by Skálová et al. SC has heterogeneous histopathological manifestations, so that definitive diagnosis of the tumor by histopathological examination is difficult. Many fusion partners of ETV6 are known in other malignant tumors. In the case of SC also, previously unknown fusion partners of ETV6 (ETV6-X) have been reported recently. Herein, we report a case of SC of the submandibular gland harboring an ETV6-X fusion gene. A 32-year-old man presented to our department with a mass in his right submandibular region that he had first noticed one month earlier. We diagnosed the mass as a submandibular gland tumor and performed submandibular gland excision. The postoperative histopathological findings led to suspicion of the tumor as a SC. Subsequently, FISH analysis led to a confirmed the diagnosis of SC with an ETV6-X fusion gene. No evidence of recurrence was noted during postoperative follow-up of the patient for 20 months without any further therapy. Because of the difficulty in the histological diagnosis and absence of any availability of established treatments for tumors harboring the NTRK family genes, it is important to perform genetic examination for confirmatory diagnosis in patients with suspected SC.
"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751155424768","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80644939"},{"@type":"NRID","@value":"1000080644939"},{"@type":"NRID","@value":"9000404826349"},{"@type":"NRID","@value":"9000415046025"},{"@type":"NRID","@value":"9000410904340"},{"@type":"NRID","@value":"9000396168466"},{"@type":"NRID","@value":"9000018281206"},{"@type":"NRID","@value":"9000258043949"},{"@type":"NRID","@value":"9000412368202"},{"@type":"NRID","@value":"9000413331907"},{"@type":"NRID","@value":"9000409880325"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000007861"}],"foaf:name":[{"@language":"en","@value":"Kato Ikuma"},{"@language":"ja","@value":"加藤 生真"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Yokohama City University"},{"@language":"ja","@value":"横浜市立大学分子病理学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335684","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904335"}],"foaf:name":[{"@language":"ja","@value":"石田 芳也"},{"@language":"en","@value":"Ishida Yoshiya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Japanese Red Cross Kitami Hospital"},{"@language":"ja","@value":"北見赤十字病院頭頸部・耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335689","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904333"}],"foaf:name":[{"@language":"en","@value":"Kono Michihisa"},{"@language":"ja","@value":"河野 通久"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Japanese Red Cross Kitami Hospital"},{"@language":"ja","@value":"北見赤十字病院頭頸部・耳鼻咽喉科"},{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科"},{"@language":"en","@value":"Asahikawa Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335683","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904337"}],"foaf:name":[{"@language":"en","@value":"Kumai Takumi"},{"@language":"ja","@value":"熊井 琢美"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335680","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904336"}],"foaf:name":[{"@language":"en","@value":"Wada Tetsuji"},{"@language":"ja","@value":"和田 哲治"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Japanese Red Cross Kitami Hospital"},{"@language":"ja","@value":"北見赤十字病院頭頸部・耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335681","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904338"}],"foaf:name":[{"@language":"ja","@value":"長門 利純"},{"@language":"en","@value":"Nagato Toshihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学病理学講座免疫病理分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335688","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904342"}],"foaf:name":[{"@language":"en","@value":"Kobayashi Hiroya"},{"@language":"ja","@value":"小林 博也"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学病理学講座免疫病理分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1420848647286107904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70896878"},{"@type":"NRID","@value":"1000070896878"},{"@type":"NRID","@value":"9000410904339"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/iwmF3NOatV8WB6dG"}],"foaf:name":[{"@language":"en","@value":"Kataoka Toshiaki"},{"@language":"ja","@value":"片岡 俊朗"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Yokohama City University"},{"@language":"ja","@value":"横浜市立大学病態病理学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335682","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904341"}],"foaf:name":[{"@language":"en","@value":"Nishihara Hiroji"},{"@language":"ja","@value":"西原 弘治"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北見赤十字病院病理診断科"},{"@language":"en","@value":"Japanese Red Cross Kitami Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410286426513335686","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410904334"}],"foaf:name":[{"@language":"en","@value":"Harabuchi Yasuaki"},{"@language":"ja","@value":"原渕 保明"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00326313"},{"@type":"EISSN","@value":"18844545"},{"@type":"NDL_BIB_ID","@value":"000000010342"},{"@type":"ISSN","@value":"00326313"},{"@type":"LISSN","@value":"00326313"},{"@type":"NCID","@value":"AN00107089"}],"prism:publicationName":[{"@language":"en","@value":"Practica Oto-Rhino-Laryngologica"},{"@language":"ja","@value":"耳鼻咽喉科臨床"},{"@language":"en","@value":"Jibi inkoka rinsho"},{"@language":"en","@value":"Practica Otologica"},{"@language":"en","@value":"Pract.Otol."},{"@language":"en","@value":"Pract.Otol. (Kyoto)"},{"@language":"ja","@value":"耳鼻臨床"}],"dc:publisher":[{"@language":"en","@value":"The Society of Practical Otolaryngology"},{"@language":"ja","@value":"耳鼻咽喉科臨床学会"}],"prism:publicationDate":"2020","prism:volume":"113","prism:number":"12","prism:startingPage":"787","prism:endingPage":"792"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/030799723"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I030799723"},{"@id":"https://www.jstage.jst.go.jp/article/jibirin/113/12/113_787/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2021100770"}],"availableAt":"2020","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=secretory%20carcinoma","dc:title":"secretory carcinoma"},{"@id":"https://cir.nii.ac.jp/all?q=submandibular%20gland","dc:title":"submandibular gland"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EETV6%3C/i%3E","dc:title":"ETV6"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3ENTRK3%3C/i%3E","dc:title":"NTRK3"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292619841604736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045384803072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895319177088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Secretory carcinoma of the breast: a tumour analogous to salivary gland acinic cell carcinoma?"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2008165869"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I030799723"},{"@type":"CROSSREF","@value":"10.5631/jibirin.113.787"},{"@type":"CIA","@value":"130007948464"},{"@type":"OPENAIRE","@value":"doi_dedup___::d2cc69ca8b37ca45456e14c921a34faf"}]}