Is There a Feasible Link between Vitamin D Receptor Genotypic and Allelic Frequencies with Analytical Biomarkers of Rheumatoid Arthritis Disease?

DOI Web Site Web Site PubMed 参考文献45件
  • IDRISS Naglaa K.
    Department of Medical Biochemistry, Faculty of Medicine, Assiut University
  • SELIM Zahraa I.
    Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assiut University
  • EL-HAKEIM Eman H.
    Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assiut University
  • EL NOUBY Fatma H.
    Department of Rheumatology and Rehabilitation, Faculty of Medicine, Aswan University
  • IBRAHIM Ahmed K.
    Department of Public Health, Faculty of Medicine, Assiut University
  • SAYYED Hayam G.
    Department of Medical Physiology, Faculty of Medicine, Assiut University
  • ELGAMAL Dalia A.
    Department of Histology and Cell Biology, Faculty of Medicine, Assiut University
  • IBRAHIM Maggie A.
    Department of Microbiology and Immunology, Faculty of Medicine, Assiut University
  • KAMAL Doaa
    Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assiut University
  • GOMA Samar H.
    Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assiut University

この論文をさがす

説明

<p>Rheumatoid arthritis (RA) is one of the most widespread autoimmune disorders and it has a genetic background with a variety of genes affecting the degradation of the immune system. Along these lines, we assessed the relationship between the BsmI, and FokI VDR polymorphisms and inflammable records identified with infections activity. Such as interleukins (IL-6, IL-8), hypoxia inducible factor-alpha (HIF-α), soluble receptor of advanced glycation end product (sRAGE), oxidized low-density lipoprotein cholesterol (oxLDL), neutrophil gelatinase-associated lipocalin (NGAL) and procollagen N-propeptide of type III collagen (P3NP) and the allelic frequencies of BsmI VDR rs1544410 and FokI VDR rs2228570 polymorphism on the RA. Total of 131 subjects [70 RA patients and 61 age and sex matched apparently healthy controls (HC)] were monitored for inflammatory biomarkers using ELISA. All patients were screened for the BsmI and FokI using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The all biomarkers were significantly higher in RA patients in comparison with HC. There were positive correlations between NGAL, oxLDL and s-RAGE, oxLDL. On BsmI, ‘GG’ and ‘AG’ genotypes were significantly associated with high RA activity as well as the frequency of genotypes ‘AG & GG” were higher in high activity RA as compared to low RA activity. However on FokI, was observed that in high activity patients the frequency of ‘CC’ & ‘CT’ was more prevalent as compared to low activity ones. These outcomes support the immunoregulatory role of vitamin D which is associated with several inflammatory diseases, signifying a credible anti-inflammatory role in perturbation of the RA.</p>

収録刊行物

参考文献 (45)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ