{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390288867187944320.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.24540/cgafa.37.1_21"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"4174452"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/4174452"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I4174452"}},{"identifier":{"@type":"DOI","@value":"10.1111/j.1741-4520.1997.tb00545.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.1997.tb00545.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.1997.tb00545.x"}},{"identifier":{"@type":"NAID","@value":"110002787972"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1997188206"}}],"dc:title":[{"@language":"en","@value":"Treatment of Mouse Preimplantation Embryos with Adriamycin, Methyl Methanesulfonate and Retinoic Acid Results in Congenital Defects"},{"@language":"ja-Kana","@value":"Treatment of mouse preimplantation embr"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"ABSTRACT Treatment  of  mouse  preimplantation  embryos  with  adriamycin  (ADM), methyl  methanesulfonate  (MMS)  and  all-trans  retinoic  acid (RA) on their  later develop- ment including implantation, growth and organogenesis were  investigated. ICR mice were treated  intraperitoneally  with  ADM  or  MMS on day 3 of gestation, or with RA on  day 4 of  gestation. The  uterine  contents  were  examined on day 18 of  gestation.  The  viable fetuses were  inspected for external and skeletal malformations. Irrespective of  the kind of chemical  agents  tested,  frequencies  of  total  malformed  fetuses  were  significantly  increased, whereas  the frequencies were considerably lower than those of  malformations in fetuses  of  dams treated with  ADM,  MMS or RA during  the period  of  organogenesis. In the  fetuses  of  ADM-treated  mice,  the  most  common  abnormality  was  umbilical  hernia, followed by  cleft palate. In the  MMS-treated fetuses,  the  most common  abnormality was cleft  palate.  Among  the  malformations  observed  in  this  study,  duplication  of  hindlimb (5/193 fetuses) induced by the treatment with RA at the preimplantation stage was a quite unique abnormality. This type of  malformation has never before been found in our historical  control  embryos  and  in  embryos  treated  with  various  kind  of  teratogens.  Based  on these results and  other  data, it is concluded that embryos at the preimplantation  stage are susceptible  to  environmental  chemical-induced  congenital  malformations."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658646930177","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30351563"},{"@type":"NRID","@value":"1000030351563"},{"@type":"NRID","@value":"9000405747190"},{"@type":"NRID","@value":"9000254597584"},{"@type":"NRID","@value":"9000391999367"},{"@type":"NRID","@value":"9000009143681"},{"@type":"NRID","@value":"9000014611523"},{"@type":"NRID","@value":"9000003102426"},{"@type":"NRID","@value":"9000003109817"},{"@type":"NRID","@value":"9000347193858"},{"@type":"NRID","@value":"9000345266531"},{"@type":"NRID","@value":"9000004393613"},{"@type":"NRID","@value":"9000021541794"},{"@type":"NRID","@value":"9000347139480"},{"@type":"NRID","@value":"9000018603590"}],"foaf:name":[{"@value":"長尾 哲二"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133826884480","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40426424"},{"@type":"NRID","@value":"1000040426424"},{"@type":"NRID","@value":"9000240070911"},{"@type":"NRID","@value":"9000365044846"},{"@type":"NRID","@value":"9000240043115"},{"@type":"NRID","@value":"9000009673158"},{"@type":"NRID","@value":"9000021914133"},{"@type":"NRID","@value":"9000021600851"},{"@type":"NRID","@value":"9000362804133"},{"@type":"NRID","@value":"9000347103389"},{"@type":"NRID","@value":"9000258713510"},{"@type":"NRID","@value":"9000003102425"},{"@type":"NRID","@value":"9000362204874"},{"@type":"NRID","@value":"9000347192644"},{"@type":"NRID","@value":"9000392069548"},{"@type":"NRID","@value":"9000350653135"},{"@type":"NRID","@value":"9000283731344"},{"@type":"NRID","@value":"9000283731675"},{"@type":"NRID","@value":"9000362804011"},{"@type":"NRID","@value":"9000347194468"},{"@type":"NRID","@value":"9000345267089"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000022267"}],"foaf:name":[{"@value":"代田 真理子"}]},{"@id":"https://cir.nii.ac.jp/crid/1581135652109122306","@type":"Researcher","foaf:name":[{"@value":"佐藤 昌子"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00372285"},{"@type":"EISSN","@value":"24331503"},{"@type":"NDL_BIB_ID","@value":"000000054101"},{"@type":"ISSN","@value":"09143505"},{"@type":"PISSN","@value":"09143505"},{"@type":"EISSN","@value":"17414520"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/09143505"},{"@type":"NCID","@value":"AN10066760"}],"prism:publicationName":[{"@language":"ja","@value":"日本先天異常学会会報"},{"@language":"en","@value":"official journal of Congeital Anomalies Research Association of Japan"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Teratology Society"},{"@language":"ja","@value":"日本先天異常学会"}],"prism:publicationDate":"1997","prism:volume":"37","prism:number":"1","prism:startingPage":"21","prism:endingPage":"29"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/4174452"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I4174452"},{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.1997.tb00545.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.1997.tb00545.x"},{"@id":"https://search.jamas.or.jp/link/ui/1997188206"}],"availableAt":"1997","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Developmental%20Biology","dc:title":"Developmental Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Embryology","dc:title":"Embryology"},{"@id":"https://cir.nii.ac.jp/all?q=General%20Medicine","dc:title":"General Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Pediatrics,%20Perinatology%20and%20Child%20Health","dc:title":"Pediatrics, Perinatology and Child Health"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143634217600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo."}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145959453312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Embryonic death, dwarfism and fetal malformations after irradiation of embryos at the zygote stage: studies on two mouse strains"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618753043968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fetal anomalies produced subsequent to treatment of zygotes with ethylene oxide or ethyl methanesulfonate are not likely due to the usual genetic causes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619292711552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Concentration Gradient of Retinoids in the Early Xenopus laevis Embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093861996800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of fetal malformations after treatment of mouse embryos with methylnitrosourea at the preimplantation stages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568573778560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutagen-induced fetal anomalies and death following treatment of females within hours after mating"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570200562176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Limb and lower-body duplications induced by retinoic acid in mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571323746048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Teratogenicity of adriamycin and daunomycin in the rat and 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Report No. 4: Deformity‐inducing (teratological) experiment"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204900801152","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205445439488","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Studies on the relation between alkylating agents-induced chromosomal aberrations and their embryotoxicities in mice. I. The reduction of the embryolethality of methyl methanesulfonate by caffeine."},{"@value":"アルキル化剤のマウスに対する染色体異状活発性と胎仔毒性との関連-1-Methyl methane-sulfonateのカフェインによる胎仔致死作用の軽減(速報)〔英文〕"},{"@language":"ja-Kana","@value":"アルキルカザイ ノ マウス ニ タイスル センショクタイ イジョウ カッパツセ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679878220544","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"DIFFERENTIAL SUSCEPTIBILITY OF RAT EMBRYOS TO METHYL METHANESULFONATE DURING THE PREGASTRULATION PERIOD"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238072446592","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Differential Staining of Cartilage and Bone in Fetal Mouse Skeleton by Alcian Blue and Alizarin Red S"}]},{"@id":"https://cir.nii.ac.jp/crid/1390570331084893312","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Retinoids and Retinoid Receptors in 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