A Case of Multiple Foreign Body Granulomas Developed on the Face and Extremities Caused by Injection with Hyaluronic Acid Fillers into Face

DOI

Bibliographic Information

Other Title
  • 顔面へのヒアルロン酸製剤注入によって顔面と四肢に異物肉芽腫が多発した1 例
Published
2021
DOI
  • 10.11340/skinresearch.20.2_104
Publisher
Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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Description

<p>A 69-year-old female with known eosinophilic fasciitis treated using 7.5 mg/day of prednisolone (PSL) was referred to our hospital for painful skin lesions following cosmetic treatment. One month before the first clinical visit, she received injections of hyaluronic acid fillers in the corners of her mouth at a cosmetic surgery clinic. Painful erythema and indurative lesions developed at the injection sites one week later, and she received hyaluronidase injections at the cosmetic surgery clinic. Subsequently, infiltrative erythema developed at non-injected sites on her face, left upper arm, and right thigh, and she was referred to our hospital. Histopathological examination of a biopsy specimen from indurated erythema on her right thigh revealed a foreign body granuloma in the subcutaneous tissue and the lower dermis. We administered 15 mg of PSL (total PSL dose :22.5 mg/day) and her symptoms gradually improved. She is currently being followed up with a tapered dose of PSL (12 mg/day). Most reported cases of foreign body granuloma after hyaluronic acid filler injections occurred at the injection sites. However, in this case, multiple cutaneous lesions of foreign body granuloma appeared at both the injected and non-injected sites. This is a rare case and suggested an association with the underlying eosinophilic fasciitis. Skin Research, 20 : 104-109, 2021 </p>

Journal

  • Hifu no kagaku

    Hifu no kagaku 20 (2), 104-109, 2021

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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