Trends in CD4+ Cell Counts, Viral Load, Treatment, Testing History, and Sociodemographic Characteristics of Newly Diagnosed HIV Patients in Osaka, Japan, From 2003 through 2017: A Descriptive Study

  • Kagiura Fumiko
    Graduate School of Biomedical and Health Sciences, Hiroshima University Faculty of Nursing, Hiroshima International University
  • Matsuyama Ryota
    Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Watanabe Dai
    AIDS Medical Center, National Hospital Organization Osaka National Hospital
  • Tsuchihashi Yuuki
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases
  • Kanou Kazuhiko
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases
  • Takahashi Takuri
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases
  • Matsui Yusuke
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases
  • Kakehashi Masayuki
    Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Sunagawa Tomimasa
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases
  • Shirasaka Takuma
    AIDS Medical Center, National Hospital Organization Osaka National Hospital

Abstract

<p>Background: The CD4 cell count of patients during diagnosis and distribution of CD4 cell counts in the patient population are important to understand infection-diagnosis interval and incidence rate of human immunodeficiency virus (HIV) infection, respectively. However, this information has not been published in Japan. This study aimed to describe the change in CD4 cell count trends and clarify the change in patients’ characteristics in association with the CD4 cell count information.</p><p>Methods: A descriptive study was conducted to analyze the medical records of patients with HIV who visited one of the largest acquired immunodeficiency syndrome (AIDS) core hospitals in western Japan. The basic characteristics, CD4 cell counts, viral loads, and diagnosis-treatment intervals between the first (2003–2010) and second (2011–2017) halves of the study duration were compared.</p><p>Results: The distribution of CD4 cell counts significantly changed between 2003–2010 and 2011–2017 (χ2 = 20.42, P < 0.001). The proportion of CD4 cell count <200 cells/mm3 increased (38.8% in 2003 to 45.9% in 2017), whereas CD4 cell count ≥500 cells/mm3 decreased (19.4% in 2003 to 12.2% in 2017). Moreover, the distributions of age groups, history of HIV screening test, patient outcomes, HIV viral load, and diagnosis-treatment interval also significantly changed (χ2 = 25.55, P < 0.001; χ2 = 8.37, P = 0.015; χ2 = 6.07, P = 0.014; χ2 = 13.36, P = 0.020; χ2 = 173.76, P < 0.001, respectively).</p><p>Conclusion: This study demonstrated the fundamental trends of the HIV epidemic in Osaka, Japan between 2003–2010 and 2011–2017 and indicated that the incidence rate of HIV was decreasing in Japan.</p>

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