Since ancient times, we have examined the anxiolytic effects of odorous compounds derived from plant extracts. Nowadays, the effects are introduced for the treatment of folk remedy. However, the neuronal mechanisms underlying the odor-induced anxiolytic effects has not fully addressed yet. In this review, the anxiolytic effects of odor of linalool (one of the major odorous compounds in lavender extract) which is triggered by olfactory input via endogenous benzodiazepine-like transmitter in the brain.
"},{"@language":"ja","@value":"古来より植物の芳香が抗不安効果を持つことは経験的に広く知られてきた．今日でもその作用は民間療法として取り入れられている．しかしながら「香気が抗不安効果を生み出すメカニズム」については未だ不明である．本稿ではリナロール（ラベンダー精油の主要香気成分の一つ）の香気が持つ抗不安作用，その作用の嗅覚依存性，そしてベンゾジアゼピン感受性GABAA受容体の関与を中心に，その基盤となる脳内メカニズムについて最新の知見をもとに解説する．
"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410290072657820416","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414337789"}],"foaf:name":[{"@language":"en","@value":"KASHIWADANI Hideki"},{"@language":"ja","@value":"柏谷 英樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"鹿児島大学大学院医歯学総合研究科統合分子生理学"},{"@language":"en","@value":"Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13482904"},{"@type":"LISSN","@value":"13482904"},{"@type":"EISSN","@value":"13497847"},{"@type":"NDL_BIB_ID","@value":"000004033901"},{"@type":"ISSN","@value":"13482904"},{"@type":"NCID","@value":"AA11827805"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Japan Association on Odor Environment"},{"@language":"ja","@value":"におい・かおり環境学会誌"},{"@language":"en","@value":"Journal of Japan Association on Odor Environment"},{"@language":"ja","@value":"におい・かおり環境学会誌"}],"dc:publisher":[{"@language":"en","@value":"Japan Association on Odor Environment"},{"@language":"ja","@value":"公益社団法人におい・かおり環境協会"}],"prism:publicationDate":"2021-03-25","prism:volume":"52","prism:number":"2","prism:startingPage":"112","prism:endingPage":"117"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/031368144"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I031368144"},{"@id":"https://www.jstage.jst.go.jp/article/jao/52/2/52_112/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2021164336"}],"availableAt":"2021-03-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Anxiolytic%20effect","dc:title":"Anxiolytic effect"},{"@id":"https://cir.nii.ac.jp/all?q=linalool","dc:title":"linalool"},{"@id":"https://cir.nii.ac.jp/all?q=olfactory%20system","dc:title":"olfactory system"},{"@id":"https://cir.nii.ac.jp/all?q=benzodiazepine","dc:title":"benzodiazepine"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%8A%97%E4%B8%8D%E5%AE%89","dc:title":"抗不安"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%AA%E3%83%8A%E3%83%AD%E3%83%BC%E3%83%AB","dc:title":"リナロール"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%97%85%E8%A6%9A%E7%B3%BB","dc:title":"嗅覚系"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%99%E3%83%B3%E3%82%BE%E3%82%B8%E3%82%A2%E3%82%BC%E3%83%94%E3%83%B3","dc:title":"ベンゾジアゼピン"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285714424441728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Linalool Odor-Induced Anxiolytic Effects in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619773319680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The use of a plus-maze to measure anxiety in the mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519822737664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Pharmacologic Treatment of Anxiety Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520780711808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Olfactory Dysfunction in COVID-19"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468555312000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An elevated plus-maze in mixed reality for studying human anxiety-related behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469510999040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The missense of smell: functional variability in the human odorant receptor repertoire"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419431260544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anxiolytic-like activity and GC–MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895311378688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mood, Anxiety and Olfactory Dysfunction in