{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390290699740734720.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.15017/26707"}},{"identifier":{"@type":"PMID","@value":"23858795"}},{"identifier":{"@type":"HDL","@value":"https://hdl.handle.net/2324/26707"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"024893869"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/024893869"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I024893869"}},{"identifier":{"@type":"NAID","@value":"120005303404"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013355672"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Species Difference in the Metabolism of 2,2',3,4',5,5'-Hexachlorobiphenyl (CB146) by Animal and Human Liver Microsomes"},{"@language":"ja","@value":"2,2',3,4',5,5'-六塩素化ビフェニル(CB146)のin vitro代謝の動物種差"},{"@language":"ja-Kana","@value":"2,2',3,4',5,5'-ロク エンソカ ビフェニル(CB146)ノ in vitro タイシャ ノ ドウブツ シュサ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The in vitro metabolism of 2, 2', 3, 4', 5, 5'-hexachlorobiphenyl (hexaCB) (CB146) was examined using liver microsomes of rats, guinea pigs, hamsters and human. Untreated animal livers produced one metabolite (M-2) in rats, three metabolites (M-1, M-2 and M-3) in guinea pigs and no metabolite in hamsters. Pretreatment of phenobarbital (PB) resulted in a marked increase of M-1 in three animals and of M-2 in guinea pigs. In contrast, pretreatment of 3-methylcholanthrene showed a significant increase of M-3 in guinea pigs and a decrease of M-2 in rats. Human liver microsomes prepared from nine Caucasians mainly formed M-2 and M-3 at a ratio of 2 : 1 and two individuals also formed one more metabolite M-1. The formation of M-1 was significantly correlated with CYP2B6 activity. By comparison of the GC-MS data of three metabolites with synthesized authentic samples, M-1 and M-2 were determined to be 3'-hydroxy (OH) -CB146 and 4-OH-CB146, respectively. However, M-3 is unclear at present except the fact that it is OH-hexaCB. These results suggest that 3'-OH-CB146 is formed by PB-inducible cytochrome P450 (CYP2B enzymes) in animal and human livers and 4-OH-CB146 is a major metabolite in rat and human liver."}],"abstractLicenseFlag":"allow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751154854912","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80271435"},{"@type":"NRID","@value":"1000080271435"},{"@type":"NRID","@value":"9000338690789"},{"@type":"NRID","@value":"9000006622361"},{"@type":"NRID","@value":"9000261022305"},{"@type":"NRID","@value":"9000402458404"},{"@type":"NRID","@value":"9000242071294"},{"@type":"NRID","@value":"9000413331121"},{"@type":"NRID","@value":"9000240038484"},{"@type":"NRID","@value":"9000265561889"},{"@type":"NRID","@value":"9000402458393"},{"@type":"NRID","@value":"9000409170958"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read_chiho6n1"}],"foaf:name":[{"@language":"en","@value":"Ohta Chiho"},{"@language":"ja","@value":"太田 千穂"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"中村学園大学栄養科学部食品衛生学研究室"},{"@language":"en","@value":"Faculty of Nutritional Sciences, Nakamura Gakuen University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410017057757019138","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Haraguchi Koichi"},{"@language":"ja","@value":"原口 浩一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Daiichi College of Pharmaceutical Sciences"},{"@language":"ja","@value":"第一薬科大学分析化学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326225668992","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90161132"},{"@type":"NRID","@value":"1000090161132"},{"@type":"NRID","@value":"9000003087535"},{"@type":"NRID","@value":"9000338690793"},{"@type":"NRID","@value":"9000252820380"},{"@type":"NRID","@value":"9000018705808"},{"@type":"NRID","@value":"9000006622368"},{"@type":"NRID","@value":"9000252820132"},{"@type":"NRID","@value":"9000261022307"},{"@type":"NRID","@value":"9000350640589"},{"@type":"NRID","@value":"9000242071289"},{"@type":"NRID","@value":"9000256471209"},{"@type":"NRID","@value":"9000254595338"},{"@type":"NRID","@value":"9000243877021"},{"@type":"NRID","@value":"9000240038480"},{"@type":"NRID","@value":"9000253210391"},{"@type":"NRID","@value":"9000021932186"},{"@type":"NRID","@value":"9000001364250"},{"@type":"NRID","@value":"9000303990502"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0048554"}],"foaf:name":[{"@language":"en","@value":"Kato Yoshihisa"},{"@language":"ja","@value":"加藤 善久"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島文理大学香川薬学部薬物動態学講座"},{"@language":"en","@value":"Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410017057757019140","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Endo Tetsuya"},{"@language":"ja","@value":"遠藤 哲也"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北海道医療大学薬学部衛生薬学講座"},{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido"}]},{"@id":"https://cir.nii.ac.jp/crid/1030566608333492609","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80136514"},{"@type":"NRID","@value":"1000080136514"},{"@type":"NRID","@value":"9000005179087"},{"@type":"NRID","@value":"9000254232657"},{"@type":"NRID","@value":"9000005129563"},{"@type":"NRID","@value":"9000254225972"},{"@type":"NRID","@value":"9000391616557"},{"@type":"NRID","@value":"9000402458406"},{"@type":"NRID","@value":"9000413331122"},{"@type":"NRID","@value":"9000392000375"},{"@type":"NRID","@value":"9000252818660"},{"@type":"NRID","@value":"9000253210550"},{"@type":"NRID","@value":"9000253210179"},{"@type":"NRID","@value":"9000002933986"},{"@type":"NRID","@value":"9000253163987"},{"@type":"NRID","@value":"9000391641226"},{"@type":"NRID","@value":"9000254235398"},{"@type":"NRID","@value":"9000402458397"},{"@type":"NRID","@value":"9000253209917"},{"@type":"NRID","@value":"9000254692680"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0036700"}],"foaf:name":[{"@language":"en","@value":"Koga Nobuyuki"},{"@language":"ja","@value":"古賀 信幸"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Nutritional Sciences, Nakamura Gakuen University"},{"@language":"ja","@value":"中村学園大学栄養科学部食品衛生学研究室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0016254X"},{"@type":"NDL_BIB_ID","@value":"000000020524"},{"@type":"ISSN","@value":"0016254X"},{"@type":"LISSN","@value":"0016254X"},{"@type":"NCID","@value":"AN00215478"}],"prism:publicationName":[{"@language":"ja","@value":"福岡醫學雜誌"}],"dc:publisher":[{"@language":"en","@value":"Fukuoka Medical Association"},{"@language":"ja","@value":"福岡医学会"}],"prism:publicationDate":"2013-04-25","prism:volume":"104","prism:number":"4","prism:startingPage":"161","prism:endingPage":"169"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/024893869"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I024893869"},{"@id":"http://hdl.handle.net/2324/26707"},{"@id":"https://search.jamas.or.jp/link/ui/2013355672"}],"availableAt":"2013-04-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E4%BB%A3%E8%AC%9D","dc:title":"代謝"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%A9%E3%83%83%E3%83%88","dc:title":"ラット"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%92%E3%83%88","dc:title":"ヒト"},{"@id":"https://cir.nii.ac.jp/all?q=CB146","dc:title":"CB146"},{"@id":"https://cir.nii.ac.jp/all?q=Metabolism","dc:title":"Metabolism"},{"@id":"https://cir.nii.ac.jp/all?q=Cytochrome%20P450","dc:title":"Cytochrome P450"},{"@id":"https://cir.nii.ac.jp/all?q=Rat","dc:title":"Rat"},{"@id":"https://cir.nii.ac.jp/all?q=Human","dc:title":"Human"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"ja","@value":"代謝"}]},{"subjectScheme":"Other","notation":[{"@language":"ja","@value":"ラット"}]},{"subjectScheme":"Other","notation":[{"@language":"ja","@value":"ヒト"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"CB146"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Metabolism"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Cytochrome 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