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Effect of tocotrienol on the primary progression of nonalcoholic steatohepatitis in a mouse model
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- Noichi Jun
- Food and Nutritional Sciences, Graduate Course of Humanities and Sciences, Ochanomizu University
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- Ishiakawa Tomoko
- Institute for Human Life Innovation, Ochanomizu University Deparatment of Human Nutrition, Seitoku University
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- Ichi Ikuyo
- Food and Nutritional Sciences, Graduate Course of Humanities and Sciences, Ochanomizu University Institute for Human Life Innovation, Ochanomizu University
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- Fujiwara Yoko
- Food and Nutritional Sciences, Graduate Course of Humanities and Sciences, Ochanomizu University Institute for Human Life Innovation, Ochanomizu University
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Description
<p>Tocotrienol (T3), a vitamin E (Vit E) isoform, is known to have both biological and antioxidant effects. Although alpha-tocopherol (α-Toc), another isoform of Vit E is suggested to be a useful treatment against nonalcoholic steatohepatitis (NASH), the effect of T3 on NASH is unclear. This study aimed to comparatively evaluate the effects of T3 and α-Toc on NASH in the early stage of NASH progression, using a recently established NASH mouse model induced by a choline-deficient l-amino acid-defined high-fat diet (CDAHFD). Six-week-old male mice were divided into four groups (n = 6 per group) and fed the CDAHFD for 1 week. The first group was given no other treatment (Pre). The other three groups continued the CDAHFD plus daily oral administration of Vit E-free corn oil (Control), corn oil containing α-Toc, or corn oil containing T3 for additional 2 weeks. Neither Vit E treatment changed the histologic features of NASH, but T3 significantly reduced the mRNA expression of several genes related to inflammation and fibrosis and α-Toc did not. These results suggested that oral T3 treatment was more effective than α-Toc at suppressing hepatic inflammation and fibrosis in the early stage of NASH progression in CDAHFD model mice.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 70 (2), 140-146, 2022
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