Narrowband ultraviolet B (NB-UVB) phototherapy has been used clinically for the treatment of atopic dermatitis (AD). Therefore, NB-UVB phototherapy could also be effective for the treatment of allergic rhinitis (AR), because AR is also a Th2-dominant disease like AD. Recently, light-emitting diodes (LEDs) that emit selective UVB spectra at a wavelength of 310 nm (NB-UVB) have been developed, that are small enough for intranasal phototherapy. In order to develop NB-UVB phototherapy for AR, we first examined the effects of NB-UVB irradiation on the H1R gene expression in HeLa cells. We demonstrated that low-dose NB-UVB irradiation reversibly suppressed PMA-induced upregulation of H1R mRNA in a wavelength-specific and dose-dependent manner, without inducing apoptosis of the HeLa cells. We then conducted an in vivo study using toluene 2,4-diisocyanate (TDI)-sensitized rats, an animal model of AR. We demonstrated that intranasal NB-UVB pre-irradiation suppressed TDI-induced upregulation of H1R mRNA in the nasal mucosa in a dose-dependent manner, without induction of DNA damage, causing suppression of the TDI-induced nasal symptoms in this animal model of AR. These findings suggest that low-dose NB-UVB phototherapy could be effectively and safely applied for the treatment of AR. Finally, we have developed a prototype of an NB-UVB phototherapy device and demonstrated its safety in phase I and early phase II clinical trials.
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Suppl."},{"@language":"ja","@value":"耳鼻咽喉科臨床 補冊"},{"@language":"en","@value":"Pract.Otol.(Kyoto)"},{"@language":"en","@value":"Jibi inkoka rinsho"},{"@language":"ja","@value":"耳鼻臨床"}],"dc:publisher":[{"@language":"en","@value":"The Society of Practical Otolaryngology"},{"@language":"ja","@value":"耳鼻咽喉科臨床学会"}],"prism:publicationDate":"2022","prism:volume":"158","prism:number":"0","prism:startingPage":"20","prism:endingPage":"28"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/031985319"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I031985319"},{"@id":"https://www.jstage.jst.go.jp/article/jibirinsuppl/158/0/158_20/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2022109247"}],"availableAt":"2022","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=allergic%20rhinitis","dc:title":"allergic rhinitis"},{"@id":"https://cir.nii.ac.jp/all?q=apoptosis","dc:title":"apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=histamine%20H%3Csub%3E1%3C/sub%3E%20receptor","dc:title":"histamine H1 receptor"},{"@id":"https://cir.nii.ac.jp/all?q=narrow-band%20ultraviolet%20B","dc:title":"narrow-band ultraviolet B"},{"@id":"https://cir.nii.ac.jp/all?q=phototherapy","dc:title":"phototherapy"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232315037312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239194284928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1receptor mRNA in HeLa cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712383165312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preseasonal prophylactic treatment with antihistamines suppresses\nnasal symptoms and expression of histamine H1 receptor mRNA in the\nnasal mucosa of patients with pollinosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618594215296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional up‐regulation of histamine receptor‐1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620644559104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093902491520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endonasal phototherapy with Rhinolight®for the treatment of allergic rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094986721536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased expression of histamine H1 receptor mRNA in allergic rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658454912000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H1 receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567450534784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of narrow‐band