{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390295027678917504.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.31662/jmaj.2022-0104"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"14494972"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/digimeta/14494972"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/14494972"}},{"identifier":{"@type":"URI","@value":"https://www.jmaj.jp/download.php?id=10.31662/jmaj.2022-0104"}},{"identifier":{"@type":"PMID","@value":"36793526"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2024062352"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"The Pathogenetic Mechanism for Moyamoya Vasculopathy Including a Possible Trigger Effect of Increased Flow Velocity"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Moyamoya disease (MMD), which commonly exhibits moyamoya vasculopathy characterized by chronic progressive steno-occlusive lesions in the circle of Willis with  \"moyamoya\"  collateral vessels, has been well known for its unique demographic and clinical features. Although the discovery of the susceptibility gene <i>RNF213</i> for MMD revealed the factor for its predominance in East Asians, the mechanisms underlying other predominant conditions (females, children, young to middle-aged adults, and anterior circulation) and lesion formation are yet to be determined. As MMD and moyamoya syndrome (MMS), which secondarily produces moyamoya vasculopathy due to pre-existing diseases, have the same vascular lesions despite differences in their original pathogenesis, they may share a common trigger for the development of vascular lesions. Thus, we herein consider a common trigger from a novel perspective on blood flow dynamics. Increased flow velocity in the middle cerebral arteries is an established predictor of stroke in sickle cell disease, which is often complicated by MMS. Flow velocity is also increased in other diseases complicated by MMS (Down syndrome, Graves' disease, irradiation, and meningitis). In addition, increased flow velocity occurs under the predominant conditions of MMD (females, children, young to middle-aged adults, and anterior circulation), suggesting a relationship between flow velocity and susceptibility to moyamoya vasculopathy. Increased flow velocity has also been detected in the non-stenotic intracranial arteries of MMD patients. In a pathogenetic overview of chronic progressive steno-occlusive lesions, a novel perspective including the trigger effect of increased flow velocity may provide insights into the mechanisms underlying their predominant conditions and lesion formation.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410295027678917504","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Abumiya Takeo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan"},{"@language":"en","@value":"Department of Neurosurgery, Miyanomori Memorial Hospital, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326204988672","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00361098"},{"@type":"NRID","@value":"1000000361098"},{"@type":"NRID","@value":"9000003594093"},{"@type":"NRID","@value":"9000017043290"},{"@type":"NRID","@value":"9000292185065"},{"@type":"NRID","@value":"9000397841583"},{"@type":"NRID","@value":"9000409316060"},{"@type":"NRID","@value":"9000283114630"},{"@type":"NRID","@value":"9000415203220"},{"@type":"NRID","@value":"9000006584001"},{"@type":"NRID","@value":"9000382049672"},{"@type":"NRID","@value":"9000253050380"},{"@type":"NRID","@value":"9000017276511"},{"@type":"NRID","@value":"9000345432483"},{"@type":"NRID","@value":"9000265253894"},{"@type":"NRID","@value":"9000258743707"},{"@type":"NRID","@value":"9000414250800"},{"@type":"NRID","@value":"9000398150758"},{"@type":"NRID","@value":"9000000314845"},{"@type":"NRID","@value":"9000316690835"},{"@type":"NRID","@value":"9000405872045"},{"@type":"NRID","@value":"9000258461689"},{"@type":"NRID","@value":"9000003613769"},{"@type":"NRID","@value":"9000312723719"},{"@type":"NRID","@value":"9000345380515"},{"@type":"NRID","@value":"9000019067314"},{"@type":"NRID","@value":"9000397424681"},{"@type":"NRID","@value":"9000263041904"},{"@type":"NRID","@value":"9000293834915"},{"@type":"NRID","@value":"9000290819509"},{"@type":"NRID","@value":"9000252876277"},{"@type":"NRID","@value":"9000257867411"},{"@type":"NRID","@value":"9000308729629"},{"@type":"NRID","@value":"9000408637610"},{"@type":"NRID","@value":"9000410319689"},{"@type":"NRID","@value":"9000283421123"},{"@type":"NRID","@value":"9000308729644"},{"@type":"NRID","@value":"9000258687098"},{"@type":"NRID","@value":"9000415409540"},{"@type":"NRID","@value":"9000014235310"},{"@type":"NRID","@value":"9000257961030"},{"@type":"NRID","@value":"9000257960677"},{"@type":"NRID","@value":"9000261036721"},{"@type":"NRID","@value":"9000412134170"},{"@type":"NRID","@value":"9000413339440"},{"@type":"NRID","@value":"9000415189482"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/miki20200505"}],"foaf:name":[{"@language":"en","@value":"Fujimura Miki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"2433328X"},{"@type":"EISSN","@value":"24333298"},{"@type":"ISSN","@value":"24333298"},{"@type":"LISSN","@value":"2433328X"}],"prism:publicationName":[{"@language":"en","@value":"JMA Journal"},{"@language":"ja","@value":"JMA Journal"}],"dc:publisher":[{"@language":"en","@value":"Japan Medical Association / The Japanese Associaiton of Medical Sciences"},{"@language":"ja","@value":"公益社団法人 日本医師会 / 日本医学会"}],"prism:publicationDate":"2023-01-16","prism:volume":"6","prism:number":"1","prism:startingPage":"16","prism:endingPage":"24"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/digimeta/14494972"},{"@id":"https://dl.ndl.go.jp/pid/14494972"},{"@id":"https://www.jmaj.jp/download.php?id=10.31662/jmaj.2022-0104"},{"@id":"https://search.jamas.or.jp/link/ui/2024062352"}],"availableAt":"2023-01-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Moyamoya%20disease","dc:title":"Moyamoya disease"},{"@id":"https://cir.nii.ac.jp/all?q=Moyamoya%20syndrome","dc:title":"Moyamoya syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Moyamoya%20vasculopathy","dc:title":"Moyamoya vasculopathy"},{"@id":"https://cir.nii.ac.jp/all?q=Pathogenetic%20mechanism","dc:title":"Pathogenetic mechanism"},{"@id":"https://cir.nii.ac.jp/all?q=Increased%20flow%20velocity","dc:title":"Increased flow velocity"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782014835072","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H03765"},{"@type":"JGN","@value":"JP19H03765"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03765/"}],"notation":[{"@language":"ja","@value":"もやもや病のエピゲノム血液バイオマーカー探索ー血漿microRNAの包括的検証ー"},{"@language":"en","@value":"Comprehensive validation of circulating microRNA signatures for Moyamoya disease early detection as an epigenome blood biomarker"}]},{"@id":"https://cir.nii.ac.jp/crid/1040010457616580864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K09275"},{"@type":"JGN","@value":"JP22K09275"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09275/"}],"notation":[{"@language":"ja","@value":"くも膜下出血後の脳血管攣縮に対する人工酸素運搬体を用いた新規治療法の開発"},{"@language":"en","@value":"Innovative Research of Neuroprotection for Delayed Cerebral Ischemia Associated with Cerebral Vasospasm after Subarachnoid Hemorrhage using Novel Hemoglobin-based Oxygen Carrier"}]},{"@id":"https://cir.nii.ac.jp/crid/1040566775678564992","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K09362"},{"@type":"JGN","@value":"JP20K09362"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K09362/"}],"notation":[{"@language":"ja","@value":"シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発"},{"@language":"en","@value":"Cilostazol may enhance the endogenous stem cell activity and thereby increase pial synangiosis after revascularization surgery for Moyamoya disease"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360588380617166720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Moyamoya Vasculopathy and Moyamoya-Related Systemic Vasculopathy: A Review With Histopathological and Genetic 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