A Preliminary Pathological Evaluation of Extracellular Volume Fraction with Contrast-enhanced Computed Tomography as a Novel Quantitative Parameter of Pancreatic Fibrosis
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- Kai Kengo
- Department of Surgery, University of Miyazaki Faculty of Medicine, Japan
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- Hiyoshi Masahide
- Department of Surgery, University of Miyazaki Faculty of Medicine, Japan
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- Imamura Naoya
- Department of Surgery, University of Miyazaki Faculty of Medicine, Japan
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- Hamada Takeomi
- Department of Surgery, University of Miyazaki Faculty of Medicine, Japan
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- Yano Koichi
- Department of Surgery, University of Miyazaki Faculty of Medicine, Japan
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- Sato Yuichiro
- Department of Diagnostic Pathology, University of Miyazaki Faculty of Medicine, Japan
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- Sakae Takehumi
- Department of Radiology, University of Miyazaki Faculty of Medicine, Japan
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- Komi Masanori
- Department of Radiology, University of Miyazaki Faculty of Medicine, Japan
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- Nakamura Takashi
- Department of Radiology, University of Miyazaki Faculty of Medicine, Japan
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- Choijookhuu Narantsog
- Department of Anatomy, Histochemistry and Cell Biology, University of Miyazaki Faculty of Medicine, Japan
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- Hishikawa Yoshitaka
- Department of Anatomy, Histochemistry and Cell Biology, University of Miyazaki Faculty of Medicine, Japan
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- Nanashima Atsushi
- Department of Surgery, University of Miyazaki Faculty of Medicine, Japan
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説明
<p>Objective The extracellular volume (ECV) calculated based on contrast-enhanced computed tomography (CT) has been reported as a novel imaging parameter reflecting the morphological change of fibrosis in several parenchymal organs. Our retrospective study assessed the validity of the ECV fraction for diagnosing pancreatic fibrosis and the appropriate imaging condition as the "equilibrium phase". </p><p>Methods In 27 patients undergoing multiphasic CT and subsequent pancreaticoduodenectomy, we investigated pathological fibrotic changes related to the ECV fraction and conducted analyses using the value obtained by subtracting the equilibrium CT value of the portal vein from that of the abdominal aorta (Ao-PVequilibrium) to estimate eligibility of the equilibrium phase. </p><p>Results In all patients, the ECV fraction showed a weak positive correlation with the collagenous compartment ratio (r=0.388, p=0.045). All patients were divided into two groups - the high-Ao-PVequilibrium group and low-Ao-PVequilibrium group - based on the median value. No significant correlation was found in the high-Ao-PVequilibrium group, whereas a significant correlation was observed in the low-Ao-PVequilibrium group (r=0.566, p=0.035). </p><p>Conclusion The ECV fraction is a possible predictive factor for histopathological pancreatic fibrosis. In its clinical application, the eligibility of the "equilibrium phase" may affect the diagnostic capability. It will be necessary to verify the imaging conditions in order to improve the accuracy of the diagnosis. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 62 (8), 1107-1115, 2023-04-15
一般社団法人 日本内科学会