Usefulness of a Formulation of 2-methacryloyloxyethyl Phosphorylcholine Polymer as a New Gargle

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  • Kurono Yuichi
    Department of Otolaryngology, Head and Neck surgery, Kagoshima University Graduate School of Medical and Dental Sciences
  • Iuchi Hiroyuki
    Department of Otolaryngology, Head and Neck surgery, Kagoshima University Graduate School of Medical and Dental Sciences
  • Yamashita Masaru
    Department of Otolaryngology, Head and Neck surgery, Kagoshima University Graduate School of Medical and Dental Sciences

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Other Title
  • 2-メタクリロイルオキシエチルホスホリルコリンポリマーの新規含嗽薬としての有用性
  • 2-メタクリロイルオキシエチルホスホリルコリンポリマー ノ シンキ ガンソウヤク ト シテ ノ ユウヨウセイ

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<p>　 To evaluate the usefulness of 2-methacryloyloxyethyl phosphorylcholine polymer (MPCP) as a gargle, we investigated the bacterial adherence inhibitory effect, moisturizing effect, and anti-inflammatory effect of MPCP37, one of the formulations of MPCP. In an in vitro experiment we counted the numbers of Streptococcus pneumoniae adhering to cultured pharyngeal epithelial cells after exposing the cells to MPCP37. We then counted the numbers of bacteria adhering to the mucosal epithelial cells of 15 healthy subjects three hours after gargling with MPCP37 and various commercially available gargles. The moisturizing effect of MPCP37 was assessed by measuring the humidity of the tongue surface with an oral moisture meter after gargling with MPCP37 and other gargles and absorbing tongue surface water with a paper towel. The anti-inflammatory effect of MPCP37 was assessed by measuring the levels of IL-8 produced by cultured pharyngeal epithelial cells in response to the stimulation with Pam3CSK4 after exposure to MPCP37. The results showed that the numbers of bacteria adhering to the epithelial cells had markedly decreased after exposure to MPCP37 and gargling with MPCP37, even with a 0.05% MPCP37 solution. The change in tongue surface moisture was significantly smaller in the group that had gargled with MPCP37. In addition, IL-8 production by cultured pharyngeal epithelial cells was significantly suppressed by exposure to MPCP37. These findings suggested that MPCP37 possesses moisturizing and anti-inflammatory effects in addition to an inhibitory effect on bacterial adherence and that it might be able to serve as a formulation of a new gargle.</p>

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