Ig-G4 RELATED DISEASE: A CASE REPORT
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- Yokoi Yuichiro
- Department of Otorhinolaryngology, Toho University Medical Center Ohashi Hospital
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- Yamaguchi Sota
- Department of Otorhinolaryngology, Toho University Medical Center Ohashi Hospital
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- Akiyama Naotaro
- Department of Otorhinolaryngology, Toho University Medical Center Ohashi Hospital
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- Yoshikawa Mamoru
- Department of Otorhinolaryngology, Toho University Medical Center Ohashi Hospital
Bibliographic Information
- Other Title
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- 口唇生検で確定診断に至った後腹膜線維症を呈するIgG4関連疾患の1例
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Description
<p>IgG4-related disease (IgG4-RD) is an inflammatory condition that exhibits diffuse or local organ swelling and hypertrophic changes with elevated serum IgG4 levels and infiltration of IgG4-positive plasma cells in multiple organs. The patient was a 72-year-old Japanese man, in whom magnetic resonance imaging (MRI) revealed retroperitoneal fibrosis with elevated serum IgG4 levels. He was referred to our department for a possible salivary gland biopsy to avoid invasive examination in the retroperitoneal region. Examinations with computed tomography and MRI failed to detect significant abnormalities in the salivary glands. Labial salivary gland biopsy was then performed under local anesthesia and resulted in diagnosis of IgG4-RD with typical histopathological findings (marked lymphoplasmacytic infiltration, fibrosis, and infiltration of IgG4-positive cells: IgG4+/IgG+ >40% and >10 IgG4+ plasma cells/HPF). This case suggests that labial salivary gland biopsy is useful as a low-invasive method for diagnosis of IgG4-RD, although a biopsy targeting the site of origin is ideal.</p>
Journal
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- JIBI INKOKA TEMBO
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JIBI INKOKA TEMBO 65 (3), 100-105, 2022-06-15
Society of Oto-rhino-laryngology Tokyo
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Details 詳細情報について
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- CRID
- 1390296442567144448
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- ISSN
- 18836429
- 03869687
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed