Organ Damage and Quality of Life in Takayasu Arteritis ― Evidence From a National Registry Analysis ―
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- Yoshifuji Hajime
- Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University
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- Nakaoka Yoshikazu
- Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute
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- Uchida Haruhito A.
- Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
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- Sugihara Takahiko
- Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine
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- Watanabe Yoshiko
- Department of General Medicine, Kawasaki Medical School
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- Funakoshi Sohei
- Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University
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- Isobe Mitsuaki
- Sakakibara Heart Institute
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- Harigai Masayoshi
- Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine
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説明
<p>Background: Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ damage and quality of life using Japan’s Intractable Disease Registry.</p><p>Methods and Results: After refining data, 2,013 of 2,795 patients were included in the study. Longer disease duration was related to a lower prevalence of disease activity symptoms, a higher prevalence of organ damage, and a higher proportion of patients requiring nursing care. Compared with men, women tended to have an earlier onset age, exhibiting longer disease duration. A higher proportion of women had aortic regurgitation and required nursing care. The proportion of female patients in employment was lower than that of the general female population, whereas no difference was observed between male patients and the general male population. Logistic regression analysis revealed that age at surveillance, brain ischemia, visual impairment/loss, and ischemic heart disease were significant factors associated with high nursing care needs (Level ≥2, with daily activity limitations).</p><p>Conclusions: Early diagnosis and effective treatment, particularly to prevent brain ischemia, visual impairment, and ischemic heart disease, may improve the quality of life of patients with Takayasu arteritis, especially women.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 88 (3), 285-294, 2024-02-22
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390299229355388160
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 033364233
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- PubMed
- 38123296
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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- 抄録ライセンスフラグ
- 使用不可