{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390299318829976192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2745/dds.38.404"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/dds/38/5/38_404/_pdf"}}],"dc:title":[{"@language":"en","@value":"Design of cell adhesive/non-adhesive synthetic polymers by controlling the nanobiointerfacial water"},{"@language":"ja","@value":"ナノバイオ界面水制御による細胞接着性／非接着性合成高分子の設計"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"When materials come into contact with biological fluids, water immediately adsorb onto the surface of materials. Water molecules play a crucial role in nanobiointerfacial interactions, including protein adsorption/desorption and cell adhesion/deadhesion on materials. To understand the role of water in the interaction of proteins and cells at biological interfaces, it is important to compare particular states of hydration water with various physicochemical properties of hydrated materials. Here, we discuss the fundamental concepts for determining the interactions of proteins and cells with hydrated materials along with selected examples corresponding to our recent studies, poly（2-methoxyethyl acrylate） （PMEA）, PMEA derivatives, zwitterionic polymers, poly（ethylene glycol）, and poly（2-oxazoline）s, and other polymers including biopolymers （DNA, RNA, proteins, and polysaccharides）. The states of water were analyzed by differential scanning calorimetry, time-resolved <i>in situ</i> attenuated total reflection infrared spectroscopy, solid-states NMR, surface force measurements, and wide variety of analytical techniques. We found that intermediate water which is loosely bound to a polymer, is a useful indicator of the biocompatibility of polymer surfaces. This finding on intermediate water provides novel insights and helps develop novel experimental models for understanding protein adsorption/cell adhesion in a wide range of polymers, and helps guiding principles to design functional polymers such as those used in biomedical applications."},{"@language":"ja","@value":"材料が生体組織液に接触すると直ちに水が材料表面に吸着する。水分子は、ナノバイオ界面におけるタンパク質吸着/脱離、細胞接着/非接着現象に影響を与える。界面現象を明らかにするためには、水和した材料の物理化学的な物性を理解することが重要である。本稿では、最近の筆者らの研究例、例えば、ポリ（2-メトキシエチルアクリレート）（PMEA）、PMEA誘導体、双性イオン型高分子、ポリエチレングリコール、ポリオキサゾリンなどの合成高分子、また、核酸、タンパク質、多糖などの生体高分子に含水した水の状態について議論する。水の状態は、熱分析や分光により解析を行った。界面に形成される特定の水の状態：中間水が、タンパク質吸着/細胞接着に大きな影響を与えることや機能性合成高分子の設計につながることを見出した。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410299318829976192","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Tanaka Masaru"},{"@language":"ja","@value":"田中 賢"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学 先導物質化学研究所 ソフトマテリアル部門 ソフトマテリアル学際化学分野"},{"@language":"en","@value":"Institute for Materials Chemistry and Engineering, Soft Materials Chemistry, Kyushu University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09135006"},{"@type":"EISSN","@value":"18812732"},{"@type":"CODEN","@value":"DDSYEI"}],"prism:publicationName":[{"@language":"en","@value":"Drug Delivery System"},{"@language":"ja","@value":"Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ"},{"@language":"en","@value":"DDS"},{"@language":"en","@value":"Official Journal of the Japan Society of Drug Delivery System"},{"@language":"ja","@value":"ＤＤＳ"}],"dc:publisher":[{"@language":"en","@value":"THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM"},{"@language":"ja","@value":"日本DDS学会"}],"prism:publicationDate":"2023-11-25","prism:volume":"38","prism:number":"5","prism:startingPage":"404","prism:endingPage":"415"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/dds/38/5/38_404/_pdf"}],"availableAt":"2023-11-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=water%20states","dc:title":"water states"},{"@id":"https://cir.nii.ac.jp/all?q=protein%20adsorption","dc:title":"protein adsorption"},{"@id":"https://cir.nii.ac.jp/all?q=cell%20adhesion","dc:title":"cell adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=intermediate%20water","dc:title":"intermediate water"},{"@id":"https://cir.nii.ac.jp/all?q=cancer%20cell","dc:title":"cancer cell"},{"@id":"https://cir.nii.ac.jp/all?q=water%20states","dc:title":"water states"},{"@id":"https://cir.nii.ac.jp/all?q=protein%20adsorption","dc:title":"protein adsorption"},{"@id":"https://cir.nii.ac.jp/all?q=cell%20adhesion","dc:title":"cell adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=intermediate%20water","dc:title":"intermediate water"},{"@id":"https://cir.nii.ac.jp/all?q=cancer%20cell","dc:title":"cancer cell"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216604507392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Poly(ω-methoxyalkyl acrylate)s: Nonthrombogenic Polymer Family with Tunable Protein Adsorption"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233138878720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regioselective Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side Chains."}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233456166912","@type":"Article","resourceType":"学術雑誌論文(journal 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Viability under Serum-Free Conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013187737115392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles of interfacial water states on advanced biomedical material design"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013188797094400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Osmolytes on Water Mobility Correlates with Their Stabilizing Effect on Proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016863444227968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biocompatible poly(<i>N</i>-(ω-acryloyloxy-<i>n</i>-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to 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I"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621228071552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Understanding the Effect of Hydration on the Bio-inert Properties of 2-Hydroxyethyl Methacrylate Copolymers with Small Amounts of Amino- or/and Fluorine-Containing Monomers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621306880512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Why do phospholipid polymers reduce protein adsorption?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643804366208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294648072391168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Side-Chain Spacing and Length on Hydration States of Poly(2-methoxyethyl acrylate) Analogues: A Molecular Dynamics Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298341432884096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of Hydration Water Bound to Choline Phosphate-Containing Polymers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345008336384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345008880128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Infrared Spectra and Hydrogen-Bond Configurations of Water Molecules at the Interface of Water-Insoluble Polymers under Humidified Conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865730078336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stealth and pseudo-stealth nanocarriers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166557912960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester): A Candidate for Blood-Compatible Polymers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166833319040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cold crystallisation behaviour of water molecules in ionic liquids as a screening method to evaluate biocompatibility of the hydrated ionic liquids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183073766656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption-Suppressing Poly(2-methoxyethyl acrylate) Analogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092436656512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092702093440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092720472576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of interfacial water in determining the interactions of proteins and cells with hydrated materials"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094265243520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of hydration and water structure in biological and colloidal interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095102431360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Study of Blood Compatibility with Poly(2-methoxyethyl acrylate). Relationship between Water Structure and Platelet Compatibility in Poly(2-methoxyethylacrylate-<i>co</i>-2-hydroxyethylmethacrylate)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096156533632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cold crystallization of water in hydrated poly(2-methoxyethyl acrylate) (PMEA)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579820399941760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Water as the often neglected medium at the interface between materials and biology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230616414080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enrichment of Cancer Cells Based on Antibody-Free Selective Cell Adhesion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845539037626752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Design of biocompatible and biodegradable polymers based on intermediate water concept"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846639539250560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641545257984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658074676864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593722266752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of bound water content on cell adhesion strength to water-insoluble polymers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593722707328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593771515776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593813315584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Poly(tertiary amide acrylate) Copolymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861291388653056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Experimental Evidence of Slow Mode Water in the Vicinity of Poly(ethylene oxide) at Physiological Temperature"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861295475078912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Observing the repulsion layers on blood-compatible polymer-grafted interfaces by frequency modulation atomic force microscopy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707356663680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship between Hydration States and Surface Morphology"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520308522624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aspects of three types of hydrogels for biomedical applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994683404672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Time-Resolved In Situ ATR-IR Observations of the Process of Sorption of Water into a Poly(2-methoxyethyl acrylate) Film"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996137978368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418802682112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Study on kinetics of early stage protein adsorption on poly(2-methoxyethylacrylate) (PMEA) surface"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421062712064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Probing Resistance to Protein Adsorption of Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers by Scanning Force Microscopy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895829263488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Blood compatible aspects of poly(2-methoxyethylacrylate) (PMEA)—relationship between protein adsorption and platelet adhesion on PMEA surface"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370781596160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In situ studies on protein adsorption onto a poly(2-methoxyethylacrylate) surface by a quartz crystal microbalance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846303094272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of water structure on blood compatibility— thermal analysis of water in poly(meth)acrylate"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846322916352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318940443520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative study on water structures in polyHEMA and polyMEA by XRD‐DSC simultaneous measurement"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794458172928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269051235712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270114662272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The effect of molecular mobility of supramolecular polymer surfaces on fibroblast adhesion"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270412666112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Blood‐compatibility‐water‐content relationships for radiation‐grafted hydrogels"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206288881408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Preparation of phospholipid polymers and their properties as polymer hydrogel membranes."},{"@value":"Preparation of Phospholipid Polylners and Their Properties as Polymer Hydrogel Membranes"},{"@value":"Preparation of phospholipid polymers and thier properties as polymer hydrogel membranes"},{"@value":"Preparation of phospholipid polymers and their properties as polymer hydrogel membrane"},{"@value":"Preparation of phospholipid polymers and their properties as hydrogel sheet"},{"@value":"Preparation of phospholipid polymers and properties as hydrogel membranes"},{"@value":"Preparation of phospholipid polymers and their properties as hydrogel membrane"},{"@value":"Preparation of phospholipid polymers their properties as polymer hydrogel membranes"},{"@value":"Preparation of phospholipids polymers and their properties as polymer hydrogel membranes."}]},{"@id":"https://cir.nii.ac.jp/crid/1390303730501268608","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"水和している生体／材料界面のキャラクタリゼーションと医療製品開発"},{"@language":"en","@value":"Characterization of the Hydrated Bio/materials Interface and Development of Medical Devices"},{"@language":"ja-Kana","@value":"スイワ シテ イル セイタイ/ザイリョウ カイメン ノ キャラクタリゼーション ト イリョウ セイヒン カイハツ"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367073503616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Design of polymeric biomaterials : the “intermediate water concept”"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2012396339"},{"@type":"CROSSREF","@value":"10.2745/dds.38.404"},{"@type":"OPENAIRE","@value":"doi_________::a0d1fb5fa30d9a50e038fd4bf046f860"},{"@type":"CROSSREF","@value":"10.5650/oleoscience.25.133_references_DOI_Y4xJ4e9pfYcU3zco15TfvQhYA6r"}]}