Chronic kidney disease compromises structural and mechanical properties of maxillary cortical bone in a rat model
-
- Yamashita Sotaro
- Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan
-
- Kondo Yusuke
- Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan
-
- Watanabe Chie
- Department of Biomaterials and Engineering, Showa University School of Dentistry, Tokyo, Japan
-
- Nodai Tomotaka
- Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan
-
- Munemasa Takashi
- Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan
-
- Mukaibo Taro
- Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan
-
- Masaki Chihiro
- Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan
-
- Shibata Yo
- Department of Biomaterials and Engineering, Showa University School of Dentistry, Tokyo, Japan
-
- Hosokawa Ryuji
- Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Japan
説明
<p>Purpose: This study aimed to investigate the effects of chronic kidney disease (CKD) on the structural and mechanical properties of the maxillary and mandibular cortical bone.</p><p>Methods: The maxillary and mandibular cortical bones from CKD model rats were used in this study. CKD-induced histological, structural, and micro-mechanical alterations were assessed using histological analyses, micro-computed tomography (CT), bone mineral density (BMD) measurements, and nanoindentation tests.</p><p>Results: Histological analyses indicated that CKD caused an increase in the number of osteoclasts and a decrease in the number of osteocytes in the maxilla. Micro-CT analysis revealed that CKD induced a void volume/cortical volume (%) increase, which was more remarkable in the maxilla than in the mandible. CKD also significantly decreased the BMD in the maxilla. In the nanoindentation stress-strain curve, the elastic-plastic transition point and loss modulus were lower in the CKD group than that in the control group in the maxilla, suggesting that CKD increased micro fragility of the maxillary bone.</p><p>Conclusions: CKD affected bone turnover in the maxillary cortical bone. Furthermore, the maxillary histological and structural properties were compromised, and micro-mechanical properties, including the elastic-plastic transition point and loss modulus, were altered by CKD.</p>
収録刊行物
-
- Journal of Prosthodontic Research
-
Journal of Prosthodontic Research 68 (2), 264-272, 2023
公益社団法人 日本補綴歯科学会