Aquaporin 3 is expressed in the basaloid cells of canine sebaceous glands
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- SONODA Hiroko
- Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan
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- TANIGUCHI Yoshiki
- Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan
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- FUJIMOTO Naruki
- Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan
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- HIGASHIJIMA Yoshiki
- Institute for Promotion of Tenure Track, University of Miyazaki, Miyazaki, Japan
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- MATSUZAKI Toshiyuki
- Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Gunma, Japan
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- HIRAI Takuya
- Department of Veterinary Pathology, University of Miyazaki, Miyazaki, Japan
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- ITOH Teruo
- Division of Animal Medical Research, Hassen-kai, Miyazaki, Japan
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- UCHIDA Kazuyuki
- Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
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- IKEDA Masahiro
- Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan
書誌事項
- 公開日
- 2024
- 資源種別
- journal article
- DOI
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- 10.1292/jvms.24-0188
- 公開者
- 公益社団法人 日本獣医学会
この論文をさがす
説明
<p>The role of aquaporin proteins (AQPs) in tumor biology has attracted attention over the past 20 years. However, the expression profiles of AQPs in canine sebaceous gland tumors remain obscure. This study was performed to clarify the expression of AQP1, 3, 5, the most studied AQPs in tumor biology, in sebaceous adenoma and sebaceous epithelioma. Among these AQPs, only AQP3 was expressed in normal tissue and both tumor types and located to only undifferentiated sebocytes (basaloid cells). A cellular proliferation marker, Ki-67, was detected only in the area including basaloid cells in both tumor types. These findings suggest that AQP3 is useful for clarifying the origin of sebaceous gland tumors, and that AQP3 may be related to sebaceous gland development.</p>
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 86 (10), 1063-1067, 2024
公益社団法人 日本獣医学会