Therapeutic Strategy Based on the Pathogenesis for Sjögren's Syndrome

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  • USHIO Aya
    Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences
  • OTSUKA Kunihiro
    Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences
  • TSUNEMATSU Takaaki
    Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences
  • ISHIMARU Naozumi
    Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences

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Description

Pathogenesis of many autoimmune diseases has been still unclear, and establishment of the radical therapy based on the pathogenesis has been coveted by a number of patients with autoimmunity. Sjögren's syndrome (SS) is well known to be one of systemic autoimmune diseases in the exocrine glands. Detailed cellular and molecular pathogenesis of SS also remains a mystery. In this review article, the history of SS mouse models and the significant findings were described and discussed according to the previous reports including our data. In addition, recent results focusing on T cell and macrophage were explained. Finally, a possible therapeutic strategy based on the results using immune checkpoint molecules was discussed. We have to overcome the challenge to help numerous patients suffering from various severe symptoms; even a journey of a thousand miles begins with a single step to solve a lot of problems in the intractable diseases.

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