{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390302172849471360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2957/kanzo.65.533"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/kanzo/65/11/65_533/_pdf"}}],"dc:title":[{"@language":"en","@value":"Liver Transplantation for Severe Alcoholic Hepatitis"},{"@language":"ja","@value":"重症アルコール性肝炎に対する肝移植の適応"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Severe alcoholic hepatitis is a serious form of alcoholic liver disease, presenting as acute-on-chronic liver failure (ACLF). A national survey on ACLF in Japan revealed that 37.2% of the cases were because of severe alcoholic hepatitis, and the 1-month mortality of severe alcoholic hepatitis can reach to 30%-50% without liver transplantation (LT). Anecdotally, a certain period of abstinence is required for listing, although recent studies have demonstrated the effectiveness of early LT for severe alcoholic hepatitis with comparable alcoholic relapse post-LT. Multidisciplinary evaluation of social and psychological aspects and family support contribute to alcoholic relapse post-LT. Therefore, further studies may be warranted to identify the LT eligibility criteria for patients with severe alcoholic hepatitis.</p>"},{"@language":"ja","@value":"<p>重症アルコール性肝炎は，アルコール性肝疾患の中で非常に重篤でacute-on-chronic liver failure（ACLF）/急性肝不全の病態を呈する．日本でのACLFの全国調査により37.2%の症例が重症アルコール性肝炎であることが明らかにされたが，重症アルコール性肝炎は移植以外の治療では一カ月以内の死亡は30-50%に達する予後不良な疾患である．アルコール性肝疾患に対する肝移植では従来一定の断酒期間が肝移植リストの条件とされてきたが，最近の報告で欧米を中心に断酒期間に制限されない早期肝移植の有効性が明らかとなってきた．断酒期間にとらわれず社会的・精神的背景や家族サポートを精神科・ソーシャルワーカーを含めて評価することで適切な症例選択が可能となることが報告されており，本邦でも重症アルコール性肝炎に対する肝移植の適応基準の検討が必要と考えられる．</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410302172849471360","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Bekki Yuki"},{"@language":"ja","@value":"別城 悠樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学大学院消化器・総合外科"},{"@language":"en","@value":"Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410302172849471361","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Yoshizumi Tomoharu"},{"@language":"ja","@value":"吉住 朋晴"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学大学院消化器・総合外科"},{"@language":"en","@value":"Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"04514203"},{"@type":"LISSN","@value":"04514203"},{"@type":"EISSN","@value":"18813593"}],"prism:publicationName":[{"@language":"en","@value":"Kanzo"},{"@language":"ja","@value":"肝臓"},{"@language":"en","@value":"Kanzo"},{"@language":"ja","@value":"肝臓"},{"@language":"en","@value":"Acta hepatologica Japonica"}],"dc:publisher":[{"@language":"en","@value":"The Japan Society of Hepatology"},{"@language":"ja","@value":"一般社団法人　日本肝臓学会"}],"prism:publicationDate":"2024-11-01","prism:volume":"65","prism:number":"11","prism:startingPage":"533","prism:endingPage":"540"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/kanzo/65/11/65_533/_pdf"}],"availableAt":"2024-11-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E9%87%8D%E7%97%87%E3%82%A2%E3%83%AB%E3%82%B3%E3%83%BC%E3%83%AB%E6%80%A7%E8%82%9D%E7%82%8E","dc:title":"重症アルコール性肝炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%82%9D%E7%A7%BB%E6%A4%8D","dc:title":"肝移植"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%81%A9%E5%BF%9C","dc:title":"適応"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%96%AD%E9%85%92%E6%9C%9F%E9%96%93","dc:title":"断酒期間"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%AB%E3%82%B3%E3%83%BC%E3%83%AB%E6%80%A7%E8%82%9D%E7%96%BE%E6%82%A3","dc:title":"アルコール性肝疾患"},{"@id":"https://cir.nii.ac.jp/all?q=severe%20alcoholic%20hepatitis","dc:title":"severe alcoholic hepatitis"},{"@id":"https://cir.nii.ac.jp/all?q=liver%20transplantation","dc:title":"liver transplantation"},{"@id":"https://cir.nii.ac.jp/all?q=indication","dc:title":"indication"},{"@id":"https://cir.nii.ac.jp/all?q=length%20of%20abstinence","dc:title":"length of abstinence"},{"@id":"https://cir.nii.ac.jp/all?q=alcohol-related%20liver%20disease","dc:title":"alcohol-related liver disease"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230210854528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Risk factors for alcohol relapse after liver transplantation for alcoholic cirrhosis in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360020999834481408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Liver transplantation for alcohol-associated liver disease: A call for national standards of best practices to monitor and bridge disparities in access and 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