Frontiers for Development of Protein Redesign Strategy in the Era of AI

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  • NAKANO Shogo
    Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka

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  • AI時代におけるタンパク質再設計法開発の最前線
  • AI ジダイ ニ オケル タンパクシツ サイセッケイホウ カイハツ ノ サイゼンセン

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<p>Protein design has become a central focus in contemporary biology and chemistry. This review highlights recent advances in protein redesign, a strategy that generates artificial proteins by introducing multiple mutations into template protein. We first examine sequence‑based approaches—ancestral sequence reconstruction （ASR） and consensus design （CD）—that are now widely adopted. We then discuss two next‑generation methods: （i） hybrid strategies that couple CD with structure‑guided rational design, and （ii） state‑of‑the‑art platforms that integrate generative artificial intelligence with conventional redesign workflows.</p>

Journal

  • Nihon Kessho Gakkaishi

    Nihon Kessho Gakkaishi 67 (3), 176-182, 2025-08-31

    The Crystallographic Society of Japan

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