高速原子間力顕微鏡のバイオイメージング応用研究

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  • 柴田 幹大
    金沢大学 ナノ生命科学研究所 金沢大学 新学術創成研究機構

書誌事項

タイトル別名
  • High-speed Atomic Force Microscopy for Bio-imaging Application
  • コウソク ゲンシ カンリョク ケンビキョウ ノ バイオイメージング オウヨウ ケンキュウ

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説明

<p>Structural biology has long been contributing to our understanding of how proteins function by providing their detailed structures. However, the revealed structures have been restricted to static snapshots, limiting the level of our understanding. This restriction is now removed by high-speed atomic force microscopy (HS-AFM) that allows direct visualization of individual protein molecules in action at sub-molecular resolution under near physiological conditions. HS-AFM studies performed in the last few years have provided new mechanistic insight into the functional mechanism of proteins. In this review, I would like to introduce our recent HS-AFM studies on proteins, including membrane proteins embedded in lipids and a DNA endonuclease. In addition, we demonstrated that developed HS-AFM for live mammalian cells is possible to image morphological changes of living hippocampal neurons.</p>

収録刊行物

  • 表面と真空

    表面と真空 62 (4), 188-193, 2019-04-10

    公益社団法人 日本表面真空学会

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