Maternal Immune Activation in Pregnant Mice Produces Offspring with Altered Hippocampal Ripples

  • Gao Mengxuan
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Orita Ken
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Ikegaya Yuji
    Graduate School of Pharmaceutical Sciences, The University of Tokyo Center for Information and Neural Networks, National Institute of Information and Communications Technology

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  • Communication to the Editor : Maternal Immune Activation in Pregnant Mice Produces Offspring with Altered Hippocampal Ripples

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<p>Psychiatric disorders, such as schizophrenia and autism spectrum disorder, are associated with sleep disturbances and deficits in memory consolidation; however, the relationship between these symptoms remains unclear. Here, we focused on hippocampal sharp-wave ripples (SWRs), a form of transient high-frequency oscillations that occur during sleep and behavioral immobility and contribute to memory consolidation. We activated the maternal immune system with polyinosinic–polycytidylic acid (poly(I : C)), one of the major pharmacological models of psychiatric disorders, to investigate whether SWR activity is altered in acute slices of the hippocampus from offspring born to poly(I : C)-treated mouse dams. Using robust continuous clustering in a low dimensional space defined by a uniform manifold approximation and projection, we found that mice with prenatal exposure to poly(I : C) exhibited different feature distributions of SWR waveforms without affecting the overall frequencies of SWR events. Based on our results, maternal immune activation leads to altered SWR patterns in offspring.</p>

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