{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390567172574491008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5582/bst.2020.03085"}},{"identifier":{"@type":"PMID","@value":"32350160"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/bst/14/4/14_2020.03085/_pdf"}},{"identifier":{"@type":"NAID","@value":"130007906511"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2021183125"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Exploration of <i>Salmonella</i> effector mutant strains on MTR4 and RRP6 degradation"},{"@value":"Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p><i>Salmonella enterica</i> serovar Typhimurium (<i>Salmonella</i>), a pathogenic bacterium, is a major cause of foodborne diseases worldwide. <i>Salmonella</i> injects multiple virulence factors, called effectors, into cells and causes multiple rearrangements of cellular biological reactions that are important for <i>Salmonella</i> proliferation and virulence. Previously, we reported that <i>Salmonella</i> infection causes loss of MTR4 and RRP6, which are nuclear RNA degradation factors, resulting in the stabilization and accumulation of unstable nuclear RNAs. This accumulation is important for the cellular defense for <i>Salmonella</i> infection. In this study, we examined a series of <i>Salmonella</i> mutant strains, most of which are strains with genes related to effectors translocated by T3SSs encoded on <i>Salmonella</i> pathogenic islands, SPI-1 and SPI-2, that have been depleted. Among 42 <i>Salmonella</i> mutants, 6 mutants' infections canceled loss of MTR4 and RRP6. Proliferation assay of <i>Salmonella</i> in the cell revealed that six mutants showed poor proliferation in the host cell, demonstrating that poor proliferation contributed to cancellation of MTR4 and RRP6 loss. This result indicates that certain events associated with <i>Salmonella</i> proliferation in host cells cause loss of MTR4 and RRP6.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410567172574491008","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410199200"}],"foaf:name":[{"@language":"en","@value":"Sun Xiaoning"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Isotope Science Center, The University of Tokyo, Tokyo, Japan."},{"@language":"en","@value":"Advanced Interdisciplinary Studies, Engineering Department, The University of Tokyo, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801198918144","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50825007"},{"@type":"NRID","@value":"1000050825007"},{"@type":"NRID","@value":"9000410199201"},{"@type":"NRID","@value":"9000278498527"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kwt"}],"foaf:name":[{"@language":"en","@value":"Kawata Kentaro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Isotope Science Center, The University of Tokyo, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410567172574491011","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410199202"}],"foaf:name":[{"@language":"en","@value":"Miki Atsuko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Isotope Science Center, The University of Tokyo, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410567172574491009","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000410199203"}],"foaf:name":[{"@language":"en","@value":"Wada Youichiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Isotope Science Center, The University of Tokyo, Tokyo, Japan."},{"@language":"en","@value":"Advanced Interdisciplinary Studies, Engineering Department, The University of Tokyo, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751141531776","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60281169"},{"@type":"NRID","@value":"1000060281169"},{"@type":"NRID","@value":"9000410199204"}],"foaf:name":[{"@language":"en","@value":"Nagahama Masami"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801201551360","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80334217"},{"@type":"NRID","@value":"1000080334217"},{"@type":"NRID","@value":"9000380982142"},{"@type":"NRID","@value":"9000410199205"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ta_87"}],"foaf:name":[{"@language":"en","@value":"Takaya Akiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan."},{"@language":"en","@value":"Medical Mycology Research Center, Chiba University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751139392640","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40294962"},{"@type":"NRID","@value":"1000040294962"},{"@type":"NRID","@value":"9000014274875"},{"@type":"NRID","@value":"9000014586910"},{"@type":"NRID","@value":"9000345403429"},{"@type":"NRID","@value":"9000412373559"},{"@type":"NRID","@value":"9000001431124"},{"@type":"NRID","@value":"9000283909765"},{"@type":"NRID","@value":"9000410199206"},{"@type":"NRID","@value":"9000278483733"},{"@type":"NRID","@value":"9000304610850"},{"@type":"NRID","@value":"9000414552808"},{"@type":"NRID","@value":"9000298893741"},{"@type":"NRID","@value":"9000018413512"},{"@type":"NRID","@value":"9000019040611"},{"@type":"NRID","@value":"9000309171243"},{"@type":"NRID","@value":"9000002585372"},{"@type":"NRID","@value":"9000412376074"},{"@type":"NRID","@value":"9000278483777"},{"@type":"NRID","@value":"9000391976452"},{"@type":"NRID","@value":"9000283860391"},{"@type":"NRID","@value":"9000253182342"},{"@type":"NRID","@value":"9000399003551"},{"@type":"NRID","@value":"9000294324790"},{"@type":"NRID","@value":"9000248202165"},{"@type":"NRID","@value":"9000342440982"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/isc"}],"foaf:name":[{"@language":"en","@value":"Akimitsu Nobuyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Isotope Science Center, The University of Tokyo, Tokyo, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"18817815"},{"@type":"EISSN","@value":"18817823"}],"prism:publicationName":[{"@language":"en","@value":"BioScience Trends"},{"@language":"ja","@value":"BioScience Trends"},{"@language":"en","@value":"BST"}],"dc:publisher":[{"@language":"en","@value":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement"},{"@language":"ja","@value":"特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会"}],"prism:publicationDate":"2020-08-31","prism:volume":"14","prism:number":"4","prism:startingPage":"255","prism:endingPage":"262"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/bst/14/4/14_2020.03085/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2021183125"}],"availableAt":"2020-08-31","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=T3SSs","dc:title":"T3SSs"},{"@id":"https://cir.nii.ac.jp/all?q=SPI-1","dc:title":"SPI-1"},{"@id":"https://cir.nii.ac.jp/all?q=SPI-2","dc:title":"SPI-2"},{"@id":"https://cir.nii.ac.jp/all?q=Flagella","dc:title":"Flagella"},{"@id":"https://cir.nii.ac.jp/all?q=MTR4","dc:title":"MTR4"},{"@id":"https://cir.nii.ac.jp/all?q=RRP6","dc:title":"RRP6"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781993291648","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02570"},{"@type":"JGN","@value":"JP18H02570"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02570/"}],"notation":[{"@language":"ja","@value":"自然免疫応答を制御する長鎖非コードRNAの機能と発現制御メカニズムの解明"},{"@language":"en","@value":"Functional 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