Herein, we provide a brief overview of the synthesis and applications of trifluoromethylpyridine (TFMP) and its derivatives in the agrochemical and pharmaceutical industries. Currently, the major use of TFMP derivatives is in the protection of crops from pests. Fluazifop-butyl was the first TFMP derivative introduced to the agrochemical market, and since then, more than 20 new TFMP-containing agrochemicals have acquired ISO common names. Several TFMP derivatives are also used in the pharmaceutical and veterinary industries; five pharmaceutical and two veterinary products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials. The biological activities of TFMP derivatives are thought to be due to the combination of the unique physicochemical properties of the fluorine atom and the unique characteristics of the pyridine moiety. It is expected that many novel applications of TFMP will be discovered in the future.
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Pestic. Sci."},{"@language":"en","@value":"Journal of Pesticide Science"},{"@language":"ja","@value":"日本農薬学会誌（Ｊｏｕｒｎａｌ ｏｆ Ｐｅｓｔｉｃｉｄｅ Ｓｃｉｅｎｃｅ）"}],"dc:publisher":[{"@language":"en","@value":"Pesticide Science Society of Japan"},{"@language":"ja","@value":"日本農薬学会"}],"prism:publicationDate":"2021-05-20","prism:volume":"46","prism:number":"2","prism:startingPage":"125","prism:endingPage":"142"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/031472884"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I031472884"},{"@id":"https://www.jstage.jst.go.jp/article/jpestics/46/2/46_D21-012/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2022035738"}],"availableAt":"2021-05-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=trifluoromethylpyridine","dc:title":"trifluoromethylpyridine"},{"@id":"https://cir.nii.ac.jp/all?q=intermediate","dc:title":"intermediate"},{"@id":"https://cir.nii.ac.jp/all?q=chemical%20properties","dc:title":"chemical 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