This study aimed to investigate the clinical features, distribution, and antimicrobial susceptibility of Nocardia species isolated from pulmonary nocardiosis cases in a tertiary hospital in China. The species were collected from January 1, 2018, to May 31, 2019, and identified using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry or polymerase chain reaction. Antimicrobial susceptibility testing was performed using the broth microdilution method. Within the 44 Nocardia species, N. farcinica was the most frequently identified species (n = 36), followed by N. nova (n = 5), N. otitidiscaviarum (n = 1), N. cyriacigeorgica (n = 1), and N. transvalensis (n = 1). The top 3 predisposing factors of pulmonary nocardiosis were chronic obstructive pulmonary disease (45.5%), hypertension (34.1%), and tuberculosis (31.8%). All 44 Nocardia species were susceptible to amikacin, trimethoprim/sulfamethoxazole, and linezolid. The resistance rates of Nocardia to amoxicillin-clavulanic acid, ciprofloxacin, clarithromycin, ceftriaxone, tobramycin, and imipenem were 4.5%, 9.1%, 79.5%, 72.7%, 63.6%, and 38.6%, respectively. Two Nocardia strains had decreased sensitivity to trimethoprim/sulfamethoxazole. In conclusion, N. farcinica was the most frequently isolated Nocardia species in the First Hospital of Changsha. All the isolated clinical Nocardia species showed susceptibility to amikacin, trimethoprim/sulfamethoxazole, and linezolid, suggesting that these drugs can be primary therapeutic choices for treating Nocardia infections.
"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410572321607460611","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414955111"}],"foaf:name":[{"@language":"en","@value":"Li Jun"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory, Xiangya Hospital, Central South University, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572321607460609","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414955112"}],"foaf:name":[{"@language":"en","@value":"Shen Hui"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory, the First Hospital of Changsha, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572321607460480","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414955113"}],"foaf:name":[{"@language":"en","@value":"Yu Ting"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory, Xiangya Hospital, Central South University, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572321607460481","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414955114"}],"foaf:name":[{"@language":"en","@value":"Tao Xiao-Yan"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory, Xiangya Hospital, Central South University, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572321607460612","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414955115"}],"foaf:name":[{"@language":"en","@value":"Hu Yong-Mei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory, Xiangya Hospital, Central South University, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572321607460608","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414955116"}],"foaf:name":[{"@language":"en","@value":"Wang Hai-Chen"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory, Xiangya Hospital, Central South University, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572321607460610","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414955117"}],"foaf:name":[{"@language":"en","@value":"Zou Ming-Xiang"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory, Xiangya Hospital, Central South University, China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13446304"},{"@type":"LISSN","@value":"13446304"},{"@type":"EISSN","@value":"18842836"},{"@type":"NDL_BIB_ID","@value":"000000160120"},{"@type":"ISSN","@value":"13446304"},{"@type":"NCID","@value":"AA1132885X"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Infectious Diseases"},{"@language":"en","@value":"Jpn J Infect Dis"}],"dc:publisher":[{"@language":"en","@value":"National Institute of Infectious Diseases"},{"@language":"ja","@value":"国立感染症研究所"}],"prism:publicationDate":"2022-01-31","prism:volume":"75","prism:number":"1","prism:startingPage":"31","prism:endingPage":"35"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/031961666"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I031961666"},{"@id":"https://www.jstage.jst.go.jp/article/yoken/75/1/75_JJID.2020.1096/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2023054798"}],"availableAt":"2022-01-31","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3ENocardia%3C/i%3E","dc:title":"Nocardia"},{"@id":"https://cir.nii.ac.jp/all?q=susceptibility","dc:title":"susceptibility"},{"@id":"https://cir.nii.ac.jp/all?q=antimicrobial%20resistance","dc:title":"antimicrobial resistance"},{"@id":"https://cir.nii.ac.jp/all?q=pulmonary%20nocardiosis","dc:title":"pulmonary nocardiosis"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144543637376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardia isolation from clinical samples with the paraffin baiting technique"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144753606016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardiosis in the south of France over a 10-years period, 2004–2014"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144849706880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification and antimicrobial susceptibility of clinical Nocardia species in a tertiary hospital in China"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145551301760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardia cyriacigeorgica is a significant pathogen responsible for nocardiosis in Japan and Thailand"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618697106560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antibiotic susceptibility testing and species identification of Nocardia isolates: a retrospective analysis of data from a French expert laboratory, 2010–2015"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168941258752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Nocardia species using matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093839811328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antimicrobial-Resistant Nocardia Isolates, Taiwan, 1998-2009"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094604898560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568835213184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Species Distribution And Antibiotic Susceptibility Of Nocardia Isolates From Yantai, China
"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568958575360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardia araoensis sp. nov. and Nocardia pneumoniae sp. nov., isolated from patients in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569086791296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ten Year Review of Pulmonary Nocardiosis: A Series of 55 Cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569972666112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A case of Nocardia transvalensis pneumonia in a 19-year-old cystic fibrosis patient"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044169409792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical features, identification, antimicrobial resistance patterns of Nocardia species in China: 2009–2017"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045009831808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Primary brain abscess with Nocardia farcinica in an immunocompetent patient"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045628220032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Application of Paraffin Bait Technique to the Isolation of\n Nocardia asteroides\n from Clinical Specimens"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994014399360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pulmonary Nocardiosis in Suspected Tuberculosis Patients: A Systematic Review and Meta-Analysis of Cross-Sectional Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994440349568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of decontamination procedures on recovery of Nocardia spp"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994907566848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pulmonary nocardiosis in Western Europe—Clinical evaluation of 43 patients and population-based estimates of hospitalization rates"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996137709696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardiosis: 7‐year experience at an Australian tertiary hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468600175744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Susceptibility profiles of Nocardia spp. to antimicrobial and antituberculotic agents detected by a microplate Alamar Blue assay"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469693703168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardiosis from 1888 to 2017"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943674957440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Analysis of Pulmonary Nocardiosis in Patients With Autoimmune Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946366445696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevalence of Nocardia species among HIV-positive patients with suspected tuberculosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418299898624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardiosis in Sudan: Current Situation and Future Perspective"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418998020480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardia nova\n as the Causative Agent in Spondylodiscitis and Psoas Abscess"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894123108608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nocardial infections: report of 22 cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368692476416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cultivation of Nocardia spp. on chemically defined media for selective recovery of isolates from clinical specimens"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370488571264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DIFFERENTIATION BETWEEN Nocardia spp. AND Mycobacterium spp.: CRITICAL ASPECTS FOR BACTERIOLOGICAL DIAGNOSIS"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844725348736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diversity, Novelty, and Antimicrobial Activity of Endophytic Actinobacteria From Mangrove Plants in Beilun Estuary National Nature Reserve of Guangxi, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319713173888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antimicrobial‐Resistant\n Nocardia\n Isolates, United States, 1995–2004"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796076464256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pulmonary nocardiosis in Chronic Obstructive Pulmonary Disease: A new clinical challenge"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268277115776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An improved screening technique for isolation of Nocardia species from sputum specimens"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268866496640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Susceptibility Profiles of Nocardia Isolates Based on Current Taxonomy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269322930944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluation of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification ofNocardiaSpecies"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270540165248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bruker Biotyper Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Nocardia, Rhodococcus, Kocuria, Gordonia, Tsukamurella, and Listeria Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204872470016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Primary Brain Abscess Caused by Nocardia otitidiscaviarum"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204874562560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pulmonary Nocardiosis: A Clinical Analysis of 30 Cases"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2009095533"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I031961666"},{"@type":"CROSSREF","@value":"10.7883/yoken.jjid.2020.1096"},{"@type":"PUBMED","@value":"34053953"},{"@type":"CIA","@value":"130008143951"}]}