Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90
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- Hirata Aya
- Department of Preventive Medicine and Public Health, Keio University School of Medicine
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- Okamura Tomonori
- Department of Preventive Medicine and Public Health, Keio University School of Medicine
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- Hirata Takumi
- Department of Public Health, Hokkaido University Faculty of Medicine
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- Sugiyama Daisuke
- Faculty of Nursing and Medical Care, Keio University
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- Ohkubo Takayoshi
- Department of Hygiene and Public Health, Teikyo University School of Medicine
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- Okuda Nagako
- Department of Health and Nutrition, University of Human Arts and Sciences
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- Kita Yoshikuni
- Tsuruga City University of Nursing
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- Hayakawa Takehito
- Research Center for Social Studies of Health and Community, Ritsumeikan University
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- Kadota Aya
- Department of Public Health, Shiga University of Medical Science
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- Kondo Keiko
- Department of Public Health, Shiga University of Medical Science
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- Miura Katsuyuki
- Department of Public Health, Shiga University of Medical Science Center for Epidemiologic Research in Asia, Shiga University of Medical Science
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- Okayama Akira
- Research Institute of Strategy for Prevention
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- Ueshima Hirotsugu
- Department of Public Health, Shiga University of Medical Science Center for Epidemiologic Research in Asia, Shiga University of Medical Science
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<p>Background: Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.</p><p>Methods: A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years.</p><p>Results: During the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01–2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years.</p><p>Conclusion: In a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 32 (7), 303-313, 2022-07-05
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