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Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90

  • Hirata Aya
    Department of Preventive Medicine and Public Health, Keio University School of Medicine
  • Okamura Tomonori
    Department of Preventive Medicine and Public Health, Keio University School of Medicine
  • Hirata Takumi
    Department of Public Health, Hokkaido University Faculty of Medicine
  • Sugiyama Daisuke
    Faculty of Nursing and Medical Care, Keio University
  • Ohkubo Takayoshi
    Department of Hygiene and Public Health, Teikyo University School of Medicine
  • Okuda Nagako
    Department of Health and Nutrition, University of Human Arts and Sciences
  • Kita Yoshikuni
    Tsuruga City University of Nursing
  • Hayakawa Takehito
    Research Center for Social Studies of Health and Community, Ritsumeikan University
  • Kadota Aya
    Department of Public Health, Shiga University of Medical Science
  • Kondo Keiko
    Department of Public Health, Shiga University of Medical Science
  • Miura Katsuyuki
    Department of Public Health, Shiga University of Medical Science Center for Epidemiologic Research in Asia, Shiga University of Medical Science
  • Okayama Akira
    Research Institute of Strategy for Prevention
  • Ueshima Hirotsugu
    Department of Public Health, Shiga University of Medical Science Center for Epidemiologic Research in Asia, Shiga University of Medical Science

Abstract

<p>Background: Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.</p><p>Methods: A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years.</p><p>Results: During the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01–2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years.</p><p>Conclusion: In a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.</p>

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