Clinical evaluation of 15 cases of multiple oral cancers with special reference to coexisting oral potentially malignant disorders

Abe Ayaka, Kono Tatsuyuki, Kawano Kenji

doi:10.5981/jjhnc.49.9

The objective of this study was to clarify the characteristics of multiple primary squamous cell carcinomas of the oral cavity, with special reference to coexisting oral potentially malignant disorders （OPMD）. We reviewed 15 patients with multiple oral cancers, who were treated at our department between January 2008 and December 2018. Of the 15 patients, four had synchronous multiple cancers, and 11 had metachronous multiple cancers. There was a female predilection （female-to-male ratio; 11:4）, and gingiva was the most prevalent site, accounting for 51.4％ of 35 cancers occurring in 15 patients. Eleven patients （73.3％） showed OPMD in the same sites as cancers or other sites. OPMD included oral lichen planus （OLP） in 5 patients, oral lichenoid lesion （OLL） in 2, oral leukoplakia in 3, and both oral leukoplakia and oral chronic hyperplastic candidiasis in 1. The rate of concordance between the sites of cancers and OPMD was 63.0％ in the 11 cases with OPMD, showing high rates in oral leukoplakia and oral chronic hyperplastic candidiasis. Only three patients had habits of smoking and alcohol drinking. This study shows that multiple oral cancers have different clinical features from those of single oral cancers and that coexistence of OPMD is closely associated with multiple occurrence of cancers in the oral cavity.

Clinical evaluation of 15 cases of multiple oral cancers with special reference to coexisting oral potentially malignant disorders

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