Partial Response to Palbociclib of Gastric Metastasis Originating from Invasive Ductal Carcinoma of the Breast: A Case Report

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  • Fukuuchi Masako
    Social Medical Corporation Yamatokai Foundation Higashiyamato Hospital Department of Breast Surgery
  • Matsuo Sadanori
    Social Medical Corporation Yamatokai Foundation Higashiyamato Hospital Department of Breast Surgery

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Other Title
  • Palbociclibにより部分奏効が得られた乳癌胃転移の１例
Published
2023
DOI
  • 10.4030/jjcs.48.21
Publisher
Japanese College of Surgeons

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<p>A 67-year-old woman had undergone partial mastectomy and axillary dissection for right breast cancer (pT1N1M0, pStage ⅡA) 16 years ago. The histopathological diagnosis was Invasive Ductal Carcinoma, Scirrhous type, ER: positive, PgR: positive, HER2: negative. After postoperative radiotherapy and postoperative chemotherapy, the patient took anastrozole for 10 years and had stopped visiting our hospital. She was referred to our hospital after an upper gastrointestinal endoscopy performed by her family physician revealed elevated lesions in the upper gastric region. After a repeat upper gastrointestinal endoscopic examination and biopsy of the lesion at our hospital, the patient was diagnosed as having intragastric metastasis from breast cancer and referred to our department. Contrast-enhanced CT showed enlarged right subclavian and mediastinal lymph nodes, and the patient was started on treatment with palbociclib + letrozole. After three months of treatment, the gastric lesions shrank in size and some fibrosis was observed histologically. The right subclavian and mediastinal lymph nodes also decreased in size. Based on the findings, the treatment response was judged as partial response. Evaluation after 24 months of treatment revealed no new metastatic lesions, and the patient was continued on treatment. Distant metastasis from breast cancer is believed to occur most frequently in the liver, lungs, and bones, and less frequently in the gastrointestinal tract. We report a case of partial response to palbociclib as first-line treatment in a patient with gastric metastasis from breast cancer that occurred 16 years after surgery.</p>

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