Effects of Past-Exercise Training on Mood-Related Behaviors and Epigenetic Modification in Mice

DOI

Bibliographic Information

Other Title
  • 過去の運動習慣が将来のうつ・不安を予防する メカニズムの解明

Description

<p>Regular exercise is effective treatment for the improvement of mental illness. However, the duration of exercise effects and the impact on future mood-related behaviors, such as anxiety and depression, remain unclear. Therefore, we determined the long-term impacts of regular exercise on mood behaviors after cessation of exercise. Moreover, we focused on epigenetics, which is one of the mechanisms for the regulation of gene expression independent of DNA sequences, in hippocampal BDNF as its underlying mechanisms. Anxiety-like behaviors as a mood-related behaviors were measured by Elevated Plus Maze test. After 4 weeks of exercise training, the anxiolytic effects were lasting after 2 weeks of exercise cessation. Meanwhile, after 4 weeks of exercise cessation, anxiety-like behaviors were increased on the contrary. In contrast to our hypothesis, hippocampal Bdnf mRNA and DNA methylation levels were unchanged after 2 and 4 weeks of exercise cessation. These results suggest that the beneficial effects on mood-related behaviors after cessation of exercise are maintained in the short term. However, over a more extended withdrawal period, they can lead to an increase in anxiety.</p>

Journal

  • DESCENTE SPORTS SCIENCE

    DESCENTE SPORTS SCIENCE 45 (0), 134-141, 2024-02-22

    THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION OF SPORTS SCIENCE

Keywords

Details 詳細情報について

  • CRID
    1390580859413060992
  • DOI
    10.57488/descente.45.0_134
  • ISSN
    27584429
    02855739
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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