{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390583469490453632.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.57444/shikokuactamedica.80.3.4_121"}},{"identifier":{"@type":"URI","@value":"https://tokushima-u.repo.nii.ac.jp/records/2012480"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2025018928"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"A case of severe interstitial lung disease developed during administration of abemaciclib but successfully rescued"},{"@language":"ja","@value":"アベマシクリブ投与中に重篤な間質性肺疾患をきたしたが救命しえた１例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Abemaciclib, Selective cyclin-dependent kinase 4 and 6 inhibitor has become available for use in hormone receptor-positive and HER2-negative unresectable or recurrent breast cancer, significantly extending progression-free survival and improving prognosis.　However, caution is necessary as in some cases it may cause drug-induced interstitial lung disease, occasionally leading to severe exacerbations.　The case involves a 75-year-old female who was emergency transported to our hospital due to dyspnea occurring 11 months after initiating abemaciclib + letrozole therapy for hormone receptor-positive, HER2-negative recurrent breast cancer.　Upon arrival, she presented with type Ⅰ respiratory failure with PCO2 : 24．5 mmHg, PO2 : 61．2 mmHg, and CT revealing ground-glass opacities in both lung fields.　Diagnosed with drug-induced interstitial lung disease, she underwent endotracheal intubation followed by steroid pulse therapy.　After three rounds of steroid pulses, symptoms gradually improved, allowing for discharge home with oxygen supplementation.　Despite the development of severe interstitial lung disease in this case, prompt initiation of treatment facilitated successful life-saving intervention.</p>"},{"@language":"ja","@value":"<p>CDK4/6阻害剤であるアベマシクリブがホルモン受容体陽性かつHER2陰性の手術不能または再発乳癌に対して使用できるようになり，無増悪生存期間が有意に延長し，予後の改善が認められている。しかし，一部の症例では薬剤性間質性肺疾患をきたすことがあり，時には重症化することもあるため注意が必要である。症例は75歳女性。ホルモン受容体陽性HER2陰性再発乳癌に対しアベマシクリブ＋レトロゾール内服開始後11ヵ月目に，呼吸困難感が出現し当院に救急搬送された。来院時，PCO2：24．5mmHg，PO2：61．2mmHgでⅠ型呼吸不全をきたしており，CTでは両側肺野に牽引性気管支拡張を伴う広範なすりガラス影を認めていた。薬剤性間質性肺疾患の診断で，人工呼吸管理下にステロイドパルス療法を行った。３度のステロイドパルスを行い症状は徐々に改善，在宅酸素療法を導入し自宅退院をすることができた。本症例では重篤な間質性肺疾患を発症したが，速やかに治療を開始することができ救命することができた。</p><p>　CDK4/6阻害薬であるアベマシクリブは，ホルモン受容体陽性かつHER2陰性の手術不能または再発乳癌に対して保険適用が認められている。CDK4/6阻害薬はホルモン受容体陽性HER2陰性再発乳癌の無増悪生存期間を有意に延長し，全生存期間の延長も報告されている1）。有害事象は一般的に管理が容易とされているが，時に重篤な間質性肺炎をきたすことが報告されている1）。2018年11月30日にわが国で発売以来，本剤に起因すると考えられる間質性肺疾患（Interstitial Lung Disease：ILD）が相次いで報告された2）。アベマシクリブが原因と考えられるILDの重症例を経験したので報告する。</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420285329316481536","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20894372"},{"@type":"NRID","@value":"1000020894372"},{"@type":"NRID","@value":"9000410615747"}],"foaf:name":[{"@language":"en","@value":"Inui Tomohiro"},{"@language":"ja","@value":"乾 友浩"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"},{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410583469490453638","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Inoue Hiroaki"},{"@language":"ja","@value":"井上 寛章"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"},{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410583469490453635","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Isomura Yuta"},{"@language":"ja","@value":"磯村 祐太"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"同　呼吸器・膠原病内科学"},{"@language":"en","@value":"Department of Respiratory Medicine and Rheumatology Graduate School of Biomedical Sciences Tokushima University, Tokushima, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410583469490453637","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Yukishige Sawaka"},{"@language":"ja","@value":"行重 佐和香"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"},{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276159086976","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00865305"},{"@type":"NRID","@value":"1000000865305"},{"@type":"NRID","@value":"9000412234202"},{"@type":"NRID","@value":"9000414201583"}],"foaf:name":[{"@language":"en","@value":"Miyamoto Naoki"},{"@language":"ja","@value":"宮本 直輝"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"},{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410583469490453633","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sasa Souichirou"},{"@language":"ja","@value":"笹 聡一郎"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"},{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410583469490453634","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Misaki Mariko"},{"@language":"ja","@value":"三崎 万理子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"},{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410583469490453636","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Goto Masakazu"},{"@language":"ja","@value":"後藤 正和"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"},{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276162918656","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40403745"},{"@type":"NRID","@value":"1000040403745"},{"@type":"NRID","@value":"9000408904660"},{"@type":"NRID","@value":"9000398993648"},{"@type":"NRID","@value":"9000381485420"},{"@type":"NRID","@value":"9000411103272"},{"@type":"NRID","@value":"9000398605476"},{"@type":"NRID","@value":"9000397948517"},{"@type":"NRID","@value":"9000389952708"},{"@type":"NRID","@value":"9000411546298"},{"@type":"NRID","@value":"9000404660291"}],"foaf:name":[{"@language":"en","@value":"Toba Hiroaki"},{"@language":"ja","@value":"鳥羽 博明"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"},{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801213727616","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90332816"},{"@type":"NRID","@value":"1000090332816"},{"@type":"NRID","@value":"9000398993640"},{"@type":"NRID","@value":"9000363175576"},{"@type":"NRID","@value":"9000411103273"},{"@type":"NRID","@value":"9000369739056"},{"@type":"NRID","@value":"9000300213507"},{"@type":"NRID","@value":"9000369739174"},{"@type":"NRID","@value":"9000345254525"},{"@type":"NRID","@value":"9000370258015"},{"@type":"NRID","@value":"9000411546294"},{"@type":"NRID","@value":"9000411103192"},{"@type":"NRID","@value":"9000397948510"},{"@type":"NRID","@value":"9000397948645"},{"@type":"NRID","@value":"9000389952714"},{"@type":"NRID","@value":"9000411546301"},{"@type":"NRID","@value":"9000400189028"},{"@type":"NRID","@value":"9000404660292"}],"foaf:name":[{"@language":"en","@value":"Takizawa Hiromitsu"},{"@language":"ja","@value":"滝沢 宏光"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic, Endocrine Surgery and Oncology, Tokushima University Graduate School, Tokushima, Japan"},{"@language":"ja","@value":"徳島大学大学院医歯薬学研究部胸部・内分泌・腫瘍外科学"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00373699"},{"@type":"EISSN","@value":"27583279"}],"prism:publicationName":[{"@language":"en","@value":"SHIKOKU ACTA MEDICA"},{"@language":"ja","@value":"四国医学雑誌"}],"dc:publisher":[{"@language":"en","@value":"Tokushima Medical Association"},{"@language":"ja","@value":"徳島医学会"}],"prism:publicationDate":"2024","prism:volume":"80","prism:number":"3.4","prism:startingPage":"121","prism:endingPage":"124"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2012480"},{"@id":"https://search.jamas.or.jp/link/ui/2025018928"}],"availableAt":"2024","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=abemaciclib","dc:title":"abemaciclib"},{"@id":"https://cir.nii.ac.jp/all?q=cyclin-dependent%20kinase%204%20and%206%20inhibitor","dc:title":"cyclin-dependent kinase 4 and 6 inhibitor"},{"@id":"https://cir.nii.ac.jp/all?q=breast%20cancer","dc:title":"breast cancer"},{"@id":"https://cir.nii.ac.jp/all?q=interstitial%20lung%20disease","dc:title":"interstitial lung disease"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"abemaciclib"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"cyclin-dependent kinase 4 and 6 inhibitor"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"breast cancer"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"interstitial lung disease"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2013424670"},{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:00906:0006784168"}]}