Cluster of Differentiation 54 (CD54), also known as intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Although CD54 has been shown to be involved in cell-to-cell adhesion and proliferation of B-cell lymphoma cell lines, the clinical significance of its expression has not yet been elucidated. We analyzed Ki-67 indices, the expression status of CD54 and its receptor (CD11a), and the intercellular distance of tumor cells in 40 diffuse large B-cell lymphoma (DLBCL) cases with vascular invasion to analyze the association of cell adhesion and proliferation status. CD54 and CD11a were simultaneously expressed (double-positive) in extra/intravascular tumor cells in 14 (35%) of the cases. Histologically, lymphoma cells of the double positive cases exhibited significantly higher Ki-67 index in extravascular tumor cells than that in the intravascular ones, while no difference was observed in lymphoma cells of the non-double positive cases. The significantly shorter extravascular intercellular distance compared with the intravascular intercellular distance suggested the association between cell-cell adhesion mediated by CD54 and cell proliferation. We further confirmed that the treatment of the recombinant LFA1 (CD11a/CD18) showed the adhesion of human DLBCL-derived cell line HBL-2 to LFA1 and increased cell viability. These findings suggest that cell-to-cell adhesion via CD54 maintains the cell proliferative activity of a subset of DLBCL. This study provides a valuable foundation upon which further research may be conducted to determine detailed mechanisms of cell-to-cell-associated and adhesion-independent cell proliferation.
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Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13464280"},{"@type":"LISSN","@value":"13464280"},{"@type":"EISSN","@value":"18809952"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Clinical and Experimental Hematopathology"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ ａｎｄ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｈｅｍａｔｏｐａｔｈｏｌｏｇｙ"},{"@language":"en","@value":"JCEH"},{"@language":"en","@value":"J Clin Exp Hematopathol"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ ａｎｄ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｈｅｍａｔｏｐａｔｈｏｌｏｇｙ"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Lymphoma Research"},{"@language":"ja","@value":"一般社団法人 日本リンパ腫学会"}],"prism:publicationDate":"2024","prism:volume":"64","prism:number":"4","prism:startingPage":"275","prism:endingPage":"285"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/jslrt/64/4/64_23002/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2025324216"}],"availableAt":"2024","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=diffuse%20large%20B-cell%20lymphoma","dc:title":"diffuse large B-cell lymphoma"},{"@id":"https://cir.nii.ac.jp/all?q=Ki-67","dc:title":"Ki-67"},{"@id":"https://cir.nii.ac.jp/all?q=CD54","dc:title":"CD54"},{"@id":"https://cir.nii.ac.jp/all?q=adhesion","dc:title":"adhesion"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143699630208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and 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