Genetic, Phylogenetic, and Serological Analysis of a Getah Virus Strain Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2022

DOI Web Site Web Site PubMed 参考文献36件
  • Matsumura Ryo
    Department of Medical Entomology, National Institute of Infectious Diseases, Japan Graduate School of Agriculture, Meiji University, Japan
  • Bannai Hiroshi
    Equine Research Institute, Japan Racing Association, Japan
  • Nemoto Manabu
    Equine Research Institute, Japan Racing Association, Japan
  • Higa Yukiko
    Department of Medical Entomology, National Institute of Infectious Diseases, Japan
  • Kai Izumi
    Department of Medical Entomology, National Institute of Infectious Diseases, Japan Graduate School of Agriculture, Meiji University, Japan
  • Sasaki Toshinori
    Department of Medical Entomology, National Institute of Infectious Diseases, Japan
  • Futami Kyoko
    Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Japan
  • Yoshikawa Akira
    Nagasaki Prefectural Institute for Environmental Research and Public Health, Japan
  • Fujita Ryosuke
    Faculty of Agriculture, Kyushu University, Japan
  • Hino Masato
    Faculty of Agriculture, Kyushu University, Japan
  • Nagata Kosuke
    Faculty of Agriculture, Kyushu University, Japan Hokkaido Research Organization, Japan
  • Kuwata Ryusei
    Faculty of Veterinary Medicine, Okayama University of Science, Japan
  • Kaku Yoshihiro
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan
  • Kobayashi Daisuke
    Department of Medical Entomology, National Institute of Infectious Diseases, Japan Management Department of Biosafety, Laboratory Animal, and Pathogen Bank, National Institute of Infectious Diseases, Japan
  • Minakawa Noboru
    Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Japan
  • Kasai Shinji
    Department of Medical Entomology, National Institute of Infectious Diseases, Japan
  • Itoyama Kyo
    Graduate School of Agriculture, Meiji University, Japan
  • Maeda Ken
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan
  • Isawa Haruhiko
    Department of Medical Entomology, National Institute of Infectious Diseases, Japan

書誌事項

タイトル別名
  • Genetic, Phylogenetic, and Serological Analysis of a Getah Virus Strain Isolated from <i>Culex tritaeniorhynchus</i> Mosquitoes in Nagasaki, Japan in 2022
公開日
2025-03-31
資源種別
journal article
DOI
  • 10.7883/yoken.jjid.2024.250
公開者
国立感染症研究所

この論文をさがす

説明

<p>Getah virus (GETV), belonging to the genus Alphavirus within the family Togaviridae, is a mosquito-borne virus that causes fever, rash, edema in horses, fatalities, and pregnancy disorders in pigs. It has caused occasional outbreaks in horse populations in Japan, China, and India, and the endemic areas are gradually expanding, particularly in Asia and Oceania. In this study, we isolated a new GETV strain from Culex tritaeniorhynchus mosquitoes collected in Nagasaki Prefecture, Japan, in 2022. Phylogenetic analysis demonstrated that this new strain, 22IH8, was more closely related to previous Chinese strains than to the strains prevalent in Japan in the 2010s. Furthermore, some amino acid substitutions in the viral proteins of strain 22IH8 were similar to those in previous Chinese strains. These results indicate that strain 22IH8 may have recently invaded the Japanese archipelago from mainland Asia. The antiserum against the current vaccine strain MI-110 demonstrated high neutralization activity against the strain 22IH8, indicating the efficiency of the current vaccine for horses in Japan.</p>

収録刊行物

参考文献 (36)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ