We experienced two cases of feline infectious peritonitis (FIP) that were treated with molnupiravir for a short period. Case 1 was a 5-year-old neutered male feline Scottish Fold, presenting to our hospital with decreased vigor, appetite, and abdominal distention. FIP virus was detected in the ascites fluid, and FIP was diagnosed. Molnupilavir (10 mg/kg BID) and prednisolone (1 mg/kg SID) were administered. On day 4, appetite and vigor recovered, ascites disappeared on day 18, and blood tests normalized; therefore, the medication was stopped. Case 2 was a 10-month-old neutered male Scottish Fold cat, diagnosed with FIP at another hospital and visited our hospital for a second opinion. The FIP virus was detected in the ascites fluid, and FIP was diagnosed. Molnupilavir (10 mg/kg BID) and prednisolone (1 mg/kg SID) were administered. On day 5, appetite and vigor recovered, ascites disappeared on day 14, and blood tests normalized on day 34; therefore, the medication was discontinued. The patients had no recurrence. Molnupiravir could be cured despite the drug was stopped if the clinical symptoms disappeared.
"},{"@language":"ja","@value":"モルヌピラビルの短期間の投与により寛解した猫伝染性腹膜炎（FIP）の 2 例を経験した。症例 1 はスコティッシュフォールド，5 歳，去勢雄。元気食欲の低下と腹部膨満を主訴に来院した。腹水検査で FIP ウイルス遺伝子が検出された。FIP と診断し，モルヌピラビル 10 mg/kg BID，プレドニゾロン 1 mg/kg SID の投与を開始した。第 4 病日には元気食欲が回復し，第 18 病日には腹水が消失し，血液検査も正常化したため，投薬を中止した。症例 2 はスコティッシュフォールド，10 カ月齢，去勢雄で他院にて FIP と診断されセカンドオピニオンで来院した。腹水検査で FIP ウイルス遺伝子が検出された。FIP と診断し，モルヌピラビル 10 mg/kg BID とプレドニゾロン 1 mg/kg SID の投与を開始した。第 5 病日には元気食欲が回復し，第 14 病日には腹水が消失し，第 34 病日には血液検査も正常化したため，投薬を中止した。いずれの症例も再発は認められない。FIP においてモヌルピラビルは臨床所見が消失した時点で休薬しても治癒する可能性があることを示した。
"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410585095042547328","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"佐橋 悠"},{"@language":"en","@value":"SAHASHI Yu"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"佐橋動物病院"},{"@language":"en","@value":"Sahashi Animal Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410585095042547331","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"佐橋 三和子"},{"@language":"en","@value":"SAHASHI Miwako"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"佐橋動物病院"},{"@language":"en","@value":"Sahashi Animal Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410585095042547329","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"中東 礼子"},{"@language":"en","@value":"NAKAHIGASHI Reiko"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"佐橋動物病院"},{"@language":"en","@value":"Sahashi Animal Hospital"},{"@language":"en","@value":"Osaka Animal Emergency center"},{"@language":"ja","@value":"大阪どうぶつ夜間急病センター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410585095042547330","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"日笠 喜朗"},{"@language":"en","@value":"HIKASA Yoshiaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Sahashi Animal Hospital"},{"@language":"ja","@value":"佐橋動物病院"},{"@language":"en","@value":"Emeritus Professor of Tottori University"},{"@language":"ja","@value":"鳥取大学名誉教授"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13446991"},{"@type":"EISSN","@value":"18811574"},{"@type":"NDL_BIB_ID","@value":"000000089990"},{"@type":"ISSN","@value":"13446991"},{"@type":"LISSN","@value":"13446991"},{"@type":"NCID","@value":"AN10478688"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Animal Clinical Medicine"},{"@language":"ja","@value":"動物臨床医学"},{"@language":"en","@value":"Dobutsu Rinsho Igaku"},{"@language":"en","@value":"Journal of Animal Clinical Medicine"},{"@language":"en","@value":"J Anim Clin Med"},{"@language":"ja","@value":"動物臨床医学"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Clinical Veterinary Medicine"},{"@language":"ja","@value":"動物臨床医学会"}],"prism:publicationDate":"2024-03-25","prism:volume":"33","prism:number":"1","prism:startingPage":"21","prism:endingPage":"25"},"url":[{"@id":"http://id.ndl.go.jp/bib/033463768"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I033463768"},{"@id":"https://search.jamas.or.jp/link/ui/2024259697"}],"availableAt":"2024-03-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=cat","dc:title":"cat"},{"@id":"https://cir.nii.ac.jp/all?q=feline%20infectious%20peritonitis","dc:title":"feline infectious peritonitis"},{"@id":"https://cir.nii.ac.jp/all?q=molnupiravir","dc:title":"molnupiravir"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%8C%AB","dc:title":"猫"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%8C%AB%E4%BC%9D%E6%9F%93%E6%80%A7%E8%85%B9%E8%86%9C%E7%82%8E","dc:title":"猫伝染性腹膜炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%A2%E3%83%AB%E3%83%8C%E3%83%94%E3%83%A9%E3%83%93%E3%83%AB","dc:title":"モルヌピラビル"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2013940894"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I033463768"}]}