凍結乾燥プロセスにおける流れの問題

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  • 中川 究也
    九州大学大学院工学研究院化学工学部門 Corresponding author

書誌事項

タイトル別名
  • Issues related to the fluid flow in freeze-drying process
  • トウケツ カンソウ プロセス ニ オケル ナガレ ノ モンダイ
公開日
2025-06-15
DOI
  • 10.3811/jjmf.2025.t007
公開者
日本混相流学会

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説明

<p>Vacuum freeze-drying is known as one of the most effective drying methods for maintaining quality among the many drying techniques. The main feature of freeze-drying is that it uses the sublimation of ice as the primary principle of dehydration. In this paper, the author will consider how freeze-drying process can be linked from a device perspective and a product quality perspective in terms of “fluid flow”. The drying rate is determined by the balance between the sublimation rate, water vapor transfer within the material, the water vapor velocity in the dryer, and the frosting velocity on the cold trap. When the water vapor velocity within the device reaches Mach 1, it enters a choked flow state. Therefore, the conductance of the device and the performance of the cold trap are critical factors determining the drying performance. During the freeze-drying process, when the product temperature remains above the glass transition temperature of the freeze-concentrated phase, the collapse of product occurs. The degree of collapse is one of the major factors affecting product quality (product shrinkage, rehydration ability, inactivation of active substances, etc.), but establishing a quantitative evaluation method for this remains a significant challenge. This study presents the results of an analysis using CFD simulation to investigate how fluid flow during the drying process determines the degree of collapse.</p>

収録刊行物

  • 混相流

    混相流 39 (2), 156-161, 2025-06-15

    日本混相流学会

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