Pleomorphic adenoma is the most common salivary gland tumor. Tyrosine-rich crystalloids （TRCs） are rarely seen in the chondromyxoid stromal component of this tumor. We report a case of pleomorphic adenoma with TRCs in 70s-year-old woman. The tumor was 65 mm in diameter and located in the right parotid gland. Microscopic examination revealed numerous floret-like TRCs in abundant myxoid stroma and myoepithelial nests. TRCs were more clearly observed by Giemsa stain. TRCs are most frequently seen in pleomorphic adenoma, however, they are also known to be seen in other salivary gland tumors, including malignant tumors, and non-neoplastic tissues. TRCs should not be a diagnostic clue for pleomorphic adenoma.
"},{"@language":"ja","@value":"要旨:多形腺腫は最も頻度が高い唾液腺腫瘍であり，稀にTyrosine-rich crystalloids（TRC）を伴うことがある。症例は70代の女性で，右耳下腺に生じた最大径65 mmの腫瘤を認めた。組織学的には豊富な粘液状間質と筋上皮細胞を主体とした腫瘍胞巣からなる多形腺腫であり，その中に花弁様の形態を呈するTRCを多数認め，Giemsa染色でより明瞭に染色された。TRCは多形腺腫で最も出現頻度が高いものの，悪性腫瘍を含むその他の腫瘍や非腫瘍性の組織でも出現することが知られており，多形腺腫と診断する根拠にしてはならない。
"}],"abstractLicenseFlag":"allow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410586499659854081","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"野口 紘嗣"},{"@language":"en","@value":"Noguchi Hiroyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences"},{"@language":"ja","@value":"鹿児島大学大学院医歯学総合研究科 病理学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1410586499659854083","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"村上 未樹"},{"@language":"en","@value":"Murakami Miki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pathology, Kagoshima University Hospital"},{"@language":"ja","@value":"鹿児島大学病院 病理部・病理診断科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410586499659854085","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"田崎 貴嗣"},{"@language":"en","@value":"Tasaki Takashi"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"鹿児島大学大学院医歯学総合研究科 病理学分野"},{"@language":"en","@value":"Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences"}]},{"@id":"https://cir.nii.ac.jp/crid/1410586499659854084","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kitazono Ikumi"},{"@language":"ja","@value":"北薗 育美"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pathology, Kagoshima University Hospital"},{"@language":"ja","@value":"鹿児島大学病院 病理部・病理診断科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410586499659854082","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Higashi Michiyo"},{"@language":"ja","@value":"東 美智代"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"鹿児島大学病院 病理部・病理診断科"},{"@language":"en","@value":"Department of Pathology, Kagoshima University Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410586499659854080","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"谷本 昭英"},{"@language":"en","@value":"Tanimoto Akihide"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences"},{"@language":"ja","@value":"鹿児島大学大学院医歯学総合研究科 病理学分野"},{"@language":"en","@value":"Department of Pathology, Kagoshima University Hospital"},{"@language":"ja","@value":"鹿児島大学病院 病理部・病理診断科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13456431"},{"@type":"EISSN","@value":"27598128"}],"prism:publicationName":[{"@language":"ja","@value":"診断病理"},{"@language":"en","@value":"Japanese Journal of Diagnostic Pathology"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Pathology"},{"@language":"ja","@value":"一般社団法人 日本病理学会"}],"prism:publicationDate":"2025","prism:volume":"42","prism:number":"3","prism:startingPage":"200","prism:endingPage":"203"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2026026222"}],"availableAt":"2025","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=parotid%20gland","dc:title":"parotid gland"},{"@id":"https://cir.nii.ac.jp/all?q=pleomorphic%20adenoma","dc:title":"pleomorphic adenoma"},{"@id":"https://cir.nii.ac.jp/all?q=tyrosine%20rich%20crystalloid","dc:title":"tyrosine rich crystalloid"},{"@id":"https://cir.nii.ac.jp/all?q=pathology","dc:title":"pathology"},{"@id":"https://cir.nii.ac.jp/all?q=parotid%20gland","dc:title":"parotid gland"},{"@id":"https://cir.nii.ac.jp/all?q=pleomorphic%20adenoma","dc:title":"pleomorphic adenoma"},{"@id":"https://cir.nii.ac.jp/all?q=tyrosine%20rich%20crystalloid","dc:title":"tyrosine rich crystalloid"},{"@id":"https://cir.nii.ac.jp/all?q=pathology","dc:title":"pathology"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2014487198"}]}