Validation of in Vivo Myocardial Strain with PET Derived Feature Tracking

DOI Web Site 16 References
  • Katahira Masataka
    Department of Cardiovascular Medicine, Fukushima Medical University School of Medicine
  • Endo Keiichiro
    Department of Cardiovascular Medicine, Fukushima Medical University School of Medicine
  • Fukushima Kenji
    Department of Radiology and Nuclear Medicine, Fukushima Medical University School of Medicine
  • Kawakubo Masateru
    Department of Health Sciences, Faculty of Medical Sciences, Kyushu University
  • Ukon Naoyuki
    Advanced Clinical Research Center, Fukushima Medical University
  • Yamakuni Ryo
    Department of Radiology and Nuclear Medicine, Fukushima Medical University School of Medicine
  • Kiko Takatoyo
    Department of Cardiovascular Medicine, Fukushima Medical University School of Medicine
  • Shimizu Takeshi
    Department of Cardiovascular Medicine, Fukushima Medical University School of Medicine
  • Ishii Shiro
    Department of Radiology and Nuclear Medicine, Fukushima Medical University School of Medicine
  • Oikawa Masayoshi
    Department of Cardiovascular Medicine, Fukushima Medical University School of Medicine
  • Ito Hiroshi
    Department of Radiology and Nuclear Medicine, Fukushima Medical University School of Medicine
  • Takeishi Yasuchika
    Department of Cardiovascular Medicine, Fukushima Medical University School of Medicine
  • Nagao Michinobu
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University

Bibliographic Information

Other Title
  • Direct Comparison with Tagging-Cine Magnetic Resonance
Published
2025
Resource Type
journal article
DOI
  • 10.17996/anc.25-00002
Publisher
Japanese Society of Nuclear Cardiology

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Description

Purpose: The aim of this study was to validate positron emission tomography feature tracking (PETFT) for assessing endocardial wall strain by comparing it with conventional tagging-cine magnetic resonance (MR) derived strain analysis (TAG).<br>Methods: Consecutive 62 patients who underwent 13N-ammonia PETMR (52 males, mean age 66 years) were enrolled. PETFT and TAG were obtained through simultaneous acquisition with electrocardiography-gated PET and cine-MR for rest scan. Global longitudinal and circumferential strain (GLS and GCS) were calculated. Correlations and Bland-Altman plots were employed to evaluate associations, bias, and 95% limit of agreement (LOA) between PETFT and TAG.<br>Results: PETFT and TAG showed significant correlations (r = 0.69 [95% CI: 0.54 to 0.80], p<0.0001; r = 0.55 [95% CI: 0.33–0.80], p<0.0001 for GCS and GLS, respectively). Bland-Altman plot showed acceptable agreements (Bias 0.7±6.7, LOA -12.5 to 13.9; Bias 1.3±5.5, LOA -9.5 to 12.0 for GCS and GLS, respectively). In patients with abnormal perfusion, the correlations were still significant (r = 0.76 [95% CI: 0.62 to 0.93], p<0.0001; r = 0.59 [95% CI: 0.18 to 0.82], p=0.007 for GCS and GLS, respectively)<br>Conclusion: PETFT has been identified as a feasible technique compared to TAG, demonstrating its potential as a novel tool for assessing wall strain in routine clinical practice. However, discrepancies in strain values may arise due to differences in algorithms and the presence of perfusion defects.

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