Incidence of the Extra-intestinal Pathogenic <i>Escherichia coli</i> (ExPEC) Infections within University Hospital population

DOI Web Site 参考文献23件
  • Nishikitani Mariko
    Division of Healthcare Digital Transformation, Data-Driven Innovation Initiative, Kyushu University, Japan
  • Okui Tasuku
    Medical Information Center, Kyushu University Hospital, Japan
  • Nohara Yasunobu
    Faculty of Advanced Science and Technology, Kumamoto University, Japan
  • Tokunaga Shoji
    Clinical Research Support Center Kyushu, Japan
  • Kiyosuke Makiko
    Department of Clinical Laboratory, Division of Diagnostic Pathology, Center for Cellular & Molecular Medicine, Kyushu University Hospital, Japan
  • Nakayama Yoshikazu
    Research and Development Division, Janssen Pharmaceutical K.K., Japan
  • Yamashita Takanori
    Medical Information Center, Kyushu University Hospital, Japan
  • Kang Dongchon
    Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Japan Kashiigaoka Rehabilitation Hospital, Japan
  • Takada Atsushi
    Medical Information Center, Kyushu University Hospital, Japan
  • Nakashima Naoki
    Division of Healthcare Digital Transformation, Data-Driven Innovation Initiative, Kyushu University, Japan Medical Information Center, Kyushu University Hospital, Japan Faculty of Medical Sciences Department of Clinical Medicine, Kyushu University, Japan
  • Momose Atsushi
    Research and Development Division, Janssen Pharmaceutical K.K., Japan

書誌事項

公開日
2025-12-26
バージョン
1
DOI
  • 10.7883/yoken.jjid.2025.155
公開者
国立感染症研究所

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説明

<p>This study estimated the incidence of extraintestinal pathogenic Escherichia coli (E. coli; ExPEC) infections at Kyushu University Hospital from 2013-2018, analyzing 63,041 hospitalized and 178,690 outpatients aged ≥20 years. ExPEC infections were defined as E. coli detection in sterile specimens or urine specimens (≥103 CFU/mL) with increased SOFA scores or urological infection diagnosis codes. The incidence rate was substantially higher in hospitalized patients (1,209.3 per 100,000 person-years) compared to outpatients (94.5 per 100,000 person-years), with females showing slightly higher rates in both groups. Age was a significant risk factor, with incidence rates increasing markedly in patients ≥60 years (inpatients: 1,431.6; outpatients: 125.3 per 100,000 person-years). Importantly, the study revealed that relying solely on diagnostic names underestimated the true number of ExPEC infection cases. The precision rate, defined as the proportion of cases (n=61) with both E. coli isolated and clinically inflammatory symptoms who received an infectious disease diagnosis (n=46), was at most 75% in female outpatients. It is suggested that comprehensive microbiological data combined with clinical criteria provides more accurate surveillance. These findings establish baseline incidence rates for ExPEC infections in a Japanese hospital setting and highlight the clinical significance of these infections, particularly in elderly hospitalized patients.</p>

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