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- YOKOYAMA Yasuhisa
- Department of Hematology, Faculty of Medicine, University of Tsukuba
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- TAKAMI Akiyoshi
- Division of Hematology, Department of Internal Medicine, Aichi Medical University
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- MORI Yasuo
- Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
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- SATO Shinya
- Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
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- SUZUKI Takahiro
- Department of Hematology, Kitasato University School of Medicine
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- GOSHO Masahiko
- Department of Biostatistics, Faculty of Medicine, University of Tsukuba
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- OBARA Naoshi
- Department of Hematology, Faculty of Medicine, University of Tsukuba
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- MIYAZAKI Yasushi
- Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
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- AKASHI Koichi
- Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
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- CHIBA Shigeru
- Department of Hematology, Faculty of Medicine, University of Tsukuba
Bibliographic Information
- Other Title
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- 成人慢性好中球減少症診療の参照ガイド
- セイジン マンセイ コウチュウキュウ ゲンショウショウ シンリョウ ノ サンショウ ガイド
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Abstract
<p>Chronic neutropenia is a rare hematological entity characterized by isolated neutropenia without anemia or thrombocytopenia. The diagnostic criteria and classification of chronic neutropenia have been more elusive in adult cases than pediatric cases. We herein propose the Reference Guide for Adult Chronic Neutropenia. In this guide, diagnosis of chronic neutropenia is based on recurrent or continuous neutropenia defined by absolute neutrophil count (ANC) less than 1,500/µl for over three or more months. Severity of chronic neutropenia is defined as follows: severe, ANC <500/µl; moderate, ANC between 500 and 1,000/µl; mild, ANC between 1,000 and 1,500/µl. In this guide, adult chronic neutropenia is classified into several types including autoimmune neutropenia, cyclic neutropenia, chronic neutropenia with T cell clone, and chronic idiopathic neutropenia with or without family history, and their clinical characteristics are described. Together with antibiotics, granulocyte colony-stimulating factors (G-CSFs) constitute the first-line treatment for adult chronic neutropenia patients at time of bacterial infections. Prophylactic use of G-CSFs or antibiotics is recommended only in selected clinical settings in severe cases.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 59 (7), 845-857, 2018
The Japanese Society of Hematology
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Keywords
Details
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- CRID
- 1390845712979745408
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- NII Article ID
- 130007430620
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 029186340
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- PubMed
- 30078793
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed