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A Young Man with Non-alcoholic Steatohepatitis and Serum Anti-mitochondrial Antibody Positivity
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- Seike Takuya
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan System Biology, Graduate School of Advanced Preventive Medical Science, Kanazawa University, Japan
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- Komura Takuya
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan
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- Shimizu Yoshiaki
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan
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- Omura Hitoshi
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan
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- Kumai Tatsuo
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan
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- Kagaya Takashi
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan
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- Ohta Hajime
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan
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- Kawashima Atsuhiro
- Department of Clinical Laboratory, National Hospital Organization Kanazawa Medical Center, Japan
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- Harada Kenichi
- Department of Human Pathology, Kanazawa University Graduate School of Medical Science, Japan
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- Kaneko Shuichi
- System Biology, Graduate School of Advanced Preventive Medical Science, Kanazawa University, Japan
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- Unoura Masashi
- Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Japan
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Description
<p>A 37-year-old obese man who was a social drinker was admitted to our hospital to undergo a detailed examination for liver injury with anti-mitochondrial antibody positivity. Abdominal ultrasonography revealed moderate fatty liver. A histological analysis showed steatosis of approximately 30% of the hepatocytes, focal necrosis, a few ballooning hepatocytes and lobular inflammation suggestive of steatohepatitis, epithelioid granuloma and irregularity of the sequence of the bile duct epithelium accompanied by lymphocyte infiltration suggestive of chronic cholangitis. He was diagnosed with non-alcoholic steatohepatitis complicated with primary biliary cholangitis. His liver injury was improved by weight loss and high-dose ursodeoxycholic acid treatment. </p>
Journal
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- Internal Medicine
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Internal Medicine 57 (21), 3093-3097, 2018-11-01
The Japanese Society of Internal Medicine
