{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390845713061312640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1625/jcam.16.53"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"029672259"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/029672259"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I029672259"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jcam/16/1/16_53/_pdf"}},{"identifier":{"@type":"NAID","@value":"130007630173"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2019259861"}}],"dc:title":[{"@language":"en","@value":"Effective Use of Coix-seed Reactive Derivatives (CRD) in Managing Photoaging of the Skin: A Case Report"},{"@language":"ja","@value":"Coix-seed Reactive Derivatives(CRD)摂取が光老化皮膚の改善に有用であった事例報告"},{"@value":"症例報告 Coix-seed Reactive Derivatives (CRD)摂取が光老化皮膚の改善に有用であった事例報告"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク Coix-seed Reactive Derivatives (CRD)セッシュ ガ ヒカリ ロウカ ヒフ ノ カイゼン ニ ユウヨウ デ アッタ ジレイ ホウコク"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Ultraviolet (UV)-induced wrinkle and pigmentation are very common in clinical practice. In this report, we presented the case of a 58-year-old man who developed wrinkle and pigmentation around right hand, face and neck for ten years. Coix-seed Reactive Derivatives (CRD) was administrated orally 2.1g twice a day for 6 months. These lesions were improved in the third month, and a dramatic response was obtained at the end of 6 months of treatment. Further research is needed to define the optimal dose and duration of CRD intake."},{"@language":"ja","@value":"ハトムギの外殻・薄皮・渋皮を含む全粒熱水抽出エキス(Coix-seed Reactive Derivatives;CRD)は，in vitroの皮膚細胞実験により，抗炎症作用と抗紫外線B波（抗UVB）作用を有することが報告されているが，ヒトにおける作用の詳細については未だ不明な点が多い．今回，CRDの経口摂取によって光老化皮膚が改善した1例を経験したので報告した．患者は，58歳男性．10年前までゴルフで手袋を着用していない右手背に日光を曝していたため，右母指に深いしわができ，手背全体にも色素沈着を認めていた．CRD含有食品（CRD 4.2 g/日）を6ヶ月間摂取し続けたところ，右手の光老化皮膚は顕著に改善した．また，顔面の色素沈着や頚部のしわも改善した．今後は，さらに症例数を増やしCRDの光老化皮膚への効果を検討する予定である．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658447009798","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60251930"},{"@type":"NRID","@value":"1000060251930"},{"@type":"ORCID","@value":"0000-0002-7542-3097"},{"@type":"NRID","@value":"9000412663708"},{"@type":"NRID","@value":"9000409288634"},{"@type":"NRID","@value":"9000402259928"},{"@type":"NRID","@value":"9000409288677"},{"@type":"NRID","@value":"9000409288673"},{"@type":"NRID","@value":"9000409288633"},{"@type":"NRID","@value":"9000404790561"},{"@type":"NRID","@value":"9000402259892"},{"@type":"NRID","@value":"9000412651330"},{"@type":"NRID","@value":"9000404790547"},{"@type":"NRID","@value":"9000402259905"},{"@type":"NRID","@value":"9000402259897"},{"@type":"NRID","@value":"9000409288624"},{"@type":"NRID","@value":"9000411207853"},{"@type":"NRID","@value":"9000404790591"},{"@type":"NRID","@value":"9000409288645"},{"@type":"NRID","@value":"9000411207842"},{"@type":"NRID","@value":"9000409288659"},{"@type":"NRID","@value":"9000409288657"},{"@type":"NRID","@value":"9000409288658"},{"@type":"NRID","@value":"9000405679152"},{"@type":"NRID","@value":"9000411207830"},{"@type":"NRID","@value":"9000411207848"},{"@type":"NRID","@value":"9000404790542"},{"@type":"NRID","@value":"9000402259925"},{"@type":"NRID","@value":"9000409288653"},{"@type":"NRID","@value":"9000409288625"},{"@type":"NRID","@value":"9000409288600"},{"@type":"NRID","@value":"9000412664074"},{"@type":"NRID","@value":"9000402260259"},{"@type":"NRID","@value":"9000409288676"},{"@type":"NRID","@value":"9000404790543"},{"@type":"NRID","@value":"9000402259900"},{"@type":"NRID","@value":"9000409288614"},{"@type":"NRID","@value":"9000409288649"}],"foaf:name":[{"@language":"en","@value":"SUZUKI Nobutaka"},{"@language":"ja","@value":"鈴木 信孝"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of MedicalScience"},{"@language":"ja","@value":"金沢大学大学院医薬保健学総合研究科 臨床研究開発補完代替医療学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572174265135618","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000402259901"}],"foaf:name":[{"@language":"en","@value":"SUGIMOTO Hayato"},{"@language":"ja","@value":"杉本 勇人"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Sugimoto Orthopedic Clinic"},{"@language":"ja","@value":"杉本接骨院"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276187437184","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60465995"},{"@type":"NRID","@value":"1000060465995"},{"@type":"ORCID","@value":"0000-0001-8674-8156"},{"@type":"NRID","@value":"9000003433488"},{"@type":"NRID","@value":"9000396099130"},{"@type":"NRID","@value":"9000402259929"},{"@type":"NRID","@value":"9000283896602"},{"@type":"NRID","@value":"9000283896639"},{"@type":"NRID","@value":"9000402259907"},{"@type":"NRID","@value":"9000396151412"},{"@type":"NRID","@value":"9000351491080"},{"@type":"NRID","@value":"9000396134982"},{"@type":"NRID","@value":"9000364194345"},{"@type":"NRID","@value":"9000398151428"},{"@type":"NRID","@value":"9000392097875"},{"@type":"NRID","@value":"9000397704684"},{"@type":"NRID","@value":"9000327924762"},{"@type":"NRID","@value":"9000388514795"},{"@type":"NRID","@value":"9000326659188"},{"@type":"NRID","@value":"9000392129103"},{"@type":"NRID","@value":"9000359878425"},{"@type":"NRID","@value":"9000413917143"},{"@type":"NRID","@value":"9000403702723"},{"@type":"NRID","@value":"9000392132167"},{"@type":"NRID","@value":"9000356595695"},{"@type":"NRID","@value":"9000250747368"},{"@type":"NRID","@value":"9000351488929"},{"@type":"NRID","@value":"9000392122033"},{"@type":"NRID","@value":"9000392117200"},{"@type":"NRID","@value":"9000258306795"},{"@type":"NRID","@value":"9000380431496"},{"@type":"NRID","@value":"9000345200490"},{"@type":"NRID","@value":"9000397949419"},{"@type":"NRID","@value":"9000392131380"},{"@type":"NRID","@value":"9000402211281"},{"@type":"NRID","@value":"9000283896551"},{"@type":"NRID","@value":"9000347546437"},{"@type":"NRID","@value":"9000402259902"},{"@type":"NRID","@value":"9000266429701"},{"@type":"NRID","@value":"9000258306067"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/SHashi"}],"foaf:name":[{"@language":"en","@value":"HASHIMOTO Shintaro"},{"@language":"ja","@value":"橋本 慎太郎"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"大名町スキンクリニック"},{"@language":"en","@value":"Daimyomachi skin Clinic"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001277375754248","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0002-3812-1604"},{"@type":"KAKEN_RESEARCHERS","@value":"60504389"},{"@type":"NRID","@value":"1000060504389"},{"@type":"NRID","@value":"9000021431625"},{"@type":"NRID","@value":"9000409288678"},{"@type":"NRID","@value":"9000404790564"},{"@type":"NRID","@value":"9000404790549"},{"@type":"NRID","@value":"9000411207849"},{"@type":"NRID","@value":"9000404790589"},{"@type":"NRID","@value":"9000409288646"},{"@type":"NRID","@value":"9000405679153"},{"@type":"NRID","@value":"9000411207847"},{"@type":"NRID","@value":"9000404790537"},{"@type":"NRID","@value":"9000409288654"},{"@type":"NRID","@value":"9000409288626"},{"@type":"NRID","@value":"9000404790544"},{"@type":"NRID","@value":"9000409288615"},{"@type":"NRID","@value":"9000409288650"}],"foaf:name":[{"@language":"en","@value":"KYO Hoko"},{"@language":"ja","@value":"許 鳳浩"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of MedicalScience"},{"@language":"ja","@value":"金沢大学大学院医薬保健学総合研究科 臨床研究開発補完代替医療学講座"},{"@language":"ja","@value":"医療法人ホスピィー・浦田クリニック"},{"@language":"en","@value":"Urata Clinic, Hospy Medical Association"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001277375754257","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0001-5133-8536"},{"@type":"NRID","@value":"9000002666535"}],"foaf:name":[{"@language":"ja","@value":"上馬塲 和夫"},{"@language":"en","@value":"UEBABA Kazuo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Urata Clinic, Hospy Medical Association"},{"@language":"ja","@value":"医療法人ホスピィー・浦田クリニック"},{"@language":"ja","@value":"帝京平成大学"},{"@language":"en","@value":"Teikyo Heisei University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13487922"},{"@type":"EISSN","@value":"13487930"},{"@type":"NDL_BIB_ID","@value":"000004235143"},{"@type":"ISSN","@value":"13487922"},{"@type":"LISSN","@value":"13487922"},{"@type":"NCID","@value":"AA12095429"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Complementary and Alternative Medicine"},{"@language":"ja","@value":"日本補完代替医療学会誌"},{"@language":"en","@value":"JJCAM"},{"@language":"ja","@value":"日代替誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society for Complementary and Alternative Medicine"},{"@language":"ja","@value":"日本補完代替医療学会"}],"prism:publicationDate":"2019-03-31","prism:volume":"16","prism:number":"1","prism:startingPage":"53","prism:endingPage":"56"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/029672259"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I029672259"},{"@id":"https://www.jstage.jst.go.jp/article/jcam/16/1/16_53/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2019259861"}],"availableAt":"2019-03-31","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%8F%E3%83%88%E3%83%A0%E3%82%AE","dc:title":"ハトムギ"},{"@id":"https://cir.nii.ac.jp/all?q=CRD","dc:title":"CRD"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%8F%E3%83%88%E3%83%A0%E3%82%AE%E5%8F%8D%E5%BF%9C%E7%94%9F%E6%88%90%E7%89%A9","dc:title":"ハトムギ反応生成物"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%89%E8%80%81%E5%8C%96","dc:title":"光老化"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%9A%AE%E8%86%9A","dc:title":"皮膚"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%89%B2%E7%B4%A0%E6%B2%88%E7%9D%80","dc:title":"色素沈着"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%81%97%E3%82%8F","dc:title":"しわ"},{"@id":"https://cir.nii.ac.jp/all?q=Coix%20lacryma-jobi%20L.%20var.%20ma-yuen%20Stapf","dc:title":"Coix lacryma-jobi L. var. ma-yuen Stapf"},{"@id":"https://cir.nii.ac.jp/all?q=CRD","dc:title":"CRD"},{"@id":"https://cir.nii.ac.jp/all?q=Coix-seed%20reactive%20derivatives","dc:title":"Coix-seed reactive derivatives"},{"@id":"https://cir.nii.ac.jp/all?q=photoaging","dc:title":"photoaging"},{"@id":"https://cir.nii.ac.jp/all?q=skin","dc:title":"skin"},{"@id":"https://cir.nii.ac.jp/all?q=pigmentation","dc:title":"pigmentation"},{"@id":"https://cir.nii.ac.jp/all?q=wrinkle","dc:title":"wrinkle"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145280656640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibitory Effects of Adlay Extract on Melanin Production and Cellular Oxygen Stress in B16F10 Melanoma Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285300162715776","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of Phenolic Compounds in Coix-seed Reactive Derivatives(CRD) by Using Liquid Chromatography/Mass Spectrometry(LC-MS)"},{"@language":"ja","@value":"液体クロマトグラフィー/ 質量分析法(LC-MS) を用いたハトムギ全粒熱水抽出エキス(CRD) 中のフェノール化合物分析"},{"@language":"ja-Kana","@value":"エキタイ クロマトグラフィー/シツリョウ ブンセキホウ(LC-MS)オ モチイタ ハトムギ ゼン リュウ ネッスイ チュウシュツ エキス(CRD)ナカ ノ フェノール カゴウブツ ブンセキ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285300162719104","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dermatitis Successfully Cured by Intake of Coix-seed Reactive Derivatives (CRD): An Observational Study"},{"@language":"ja","@value":"ハトムギ全粒熱水抽出エキス (CRD) 摂取が有用と思われた皮膚炎例：事例研究"},{"@value":"症例報告 ハトムギ全粒熱水抽出エキス(CRD)摂取が有用と思われた皮膚炎例 : 事例研究"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク ハトムギ ゼン リュウ ネッスイ チュウシュツ エキス(CRD)セッシュ ガ ユウヨウ ト オモワレタ ヒフエンレイ : ジレイ ケンキュウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390285300162773120","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case of Hand Eczema Cured by Intake of Coix-seed Reactive Derivatives (CRD)"},{"@language":"ja","@value":"ハトムギ全粒熱水抽出エキス(CRD) 摂取が手湿疹の改善に有用と思われた事例報告"},{"@value":"症例報告 ハトムギ全粒熱水抽出エキス(CRD)摂取が手湿疹の改善に有用と思われた事例報告"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク ハトムギ ゼン リュウ ネッスイ チュウシュツ エキス(CRD)セッシュ ガ テ シッシン ノ カイゼン ニ ユウヨウ ト オモワレタ ジレイ ホウコク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390848250116137856","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two Cases of Plantar Keratosis Successfully Cured by Intake of Coix-seed Reactive Derivatives (CRD)"},{"@language":"ja","@value":"ハトムギ全粒熱水抽出エキス(CRD) 摂取が有用と思われた足底角化症"},{"@value":"症例報告 ハトムギ全粒熱水抽出エキス(CRD)摂取が有用と思われた足底角化症"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク ハトムギ ゼン リュウ ネッスイ チュウシュツ エキス(CRD)セッシュ ガ ユウヨウ ト オモワレタ ソクテイ カクカショウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390848250116140288","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two Cases of Plantar Wart Successfully Cured by Intake of Coix-seed Reactive Derivatives (CRD)"},{"@language":"ja","@value":"ハトムギ全粒熱水抽出エキス(CRD) 摂取により根治した足底疣贅例"},{"@value":"症例報告 ハトムギ全粒熱水抽出エキス(CRD)摂取により根治した足底疣贅例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク ハトムギ ゼン リュウ ネッスイ チュウシュツ エキス(CRD)セッシュ ニ ヨリ コンジ シタ 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